Functional neuronal anisotropy assessed with neuronavigated transcranial magnetic stimulation

Elisa Kallioniemi, Mervi Könönen, Laura Säisänen, Heidi Gröhn, Petro Julkunen

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: Transcranial magnetic stimulation (TMS) can evaluate cortical excitability and integrity of motor pathways via TMS-induced responses. The responses are affected by the orientation of the stimulated neurons with respect to the direction of the TMS-induced electric field. Therefore, besides being a functional imaging tool, TMS may potentially assess the local structural properties. Yet, TMS has not been used for this purpose. New method: A novel principle to evaluate the relation between function and structure of the motor cortex is presented. This functional anisotropy is evaluated by an anisotropy index (AI), based on motor evoked potential amplitudes induced with different TMS coil orientations, i.e. different electric field directions at a cortical target. To compare the AI with anatomical anisotropy in an explorative manner, diffusion tensor imaging-derived fractional anisotropy (FA) was estimated at different depths near the stimulation site. Results: AI correlated inversely with cortical excitability through the TMS-induced electric field at motor threshold level. Further, there was a trend of negative correlation between AI and FA. Comparison with existing methods: None of the existing methods alone can detect the relationship between direct motor cortex activation and local neuronal structure. Conclusions: The AI appears to provide information on the functional neuronal anisotropy of the motor cortex by coupling neurophysiology and neuroanatomy within the stimulated cortical region. The AI could prove useful in the evaluation of neurological disorders and traumas involving concurrent structural and functional changes in the motor cortex. Further studies on patients are needed to confirm the usability of AI.

Original languageEnglish (US)
Pages (from-to)82-90
Number of pages9
JournalJournal of Neuroscience Methods
Volume256
DOIs
StatePublished - Dec 30 2015

Bibliographical note

Funding Information:
This study was funded by the Kuopio University Hospital, Kuopio, Finland (EVO, VTR 5041730); Orion-Farmos Research Foundation, Espoo, Finland ; Kaute Foundation, Helsinki, Finland ; The Finnish Brain Research and Rehabilitation Center Neuron, Kuopio, Finland ; The Finnish Concordia Fund, Helsinki, Finland ; and The Paulo Foundation, Helsinki, Finland . The funders had no further role in study design; in the collection, analysis and interpretation of data; in the writing; and in the decision to submit the paper for publication. Further, the authors thank PhD Gerald Netto for language editing the text.

Keywords

  • Diffusion tensor imaging
  • Motor cortex
  • Motor evoked potential
  • Neuroanatomy
  • Neurophysiology
  • Transcranial magnetic stimulation

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