TY - JOUR
T1 - Functional MRI detection of hemodynamic response of repeated median nerve stimulation
AU - Ai, Leo
AU - Oya, Hiroyuki
AU - Howard, Matthew
AU - Xiong, Jinhu
PY - 2013/5
Y1 - 2013/5
N2 - Median nerve stimulation is a commonly used technique in the clinical setting to determine areas of neuronal function in the brain. Neuronal activity of repeated median nerve stimulation is well studied. The cerebral hemodynamic response of the stimulation, on the other hand, is not very clear. In this study, we investigate how cerebral hemodynamics behave over time using the same repeated median nerve stimulation. Ten subjects received constant repeated electrical stimulation to the right median nerve. Each subject had functional magnetic resonance imaging scans while receiving said stimulations for seven runs. Our results show that the blood oxygen level-dependent (BOLD) signal significantly decreases across each run. Significant BOLD signal decreases can also be seen within runs. These results are consistent with studies that have studied the hemodynamic habituation effect with other forms of stimulation. However, the results do not completely agree with the findings of studies where evoked potentials were examined. Thus, further inquiry of how evoked potentials and cerebral hemodynamics are coupled when using constant stimulations is needed.
AB - Median nerve stimulation is a commonly used technique in the clinical setting to determine areas of neuronal function in the brain. Neuronal activity of repeated median nerve stimulation is well studied. The cerebral hemodynamic response of the stimulation, on the other hand, is not very clear. In this study, we investigate how cerebral hemodynamics behave over time using the same repeated median nerve stimulation. Ten subjects received constant repeated electrical stimulation to the right median nerve. Each subject had functional magnetic resonance imaging scans while receiving said stimulations for seven runs. Our results show that the blood oxygen level-dependent (BOLD) signal significantly decreases across each run. Significant BOLD signal decreases can also be seen within runs. These results are consistent with studies that have studied the hemodynamic habituation effect with other forms of stimulation. However, the results do not completely agree with the findings of studies where evoked potentials were examined. Thus, further inquiry of how evoked potentials and cerebral hemodynamics are coupled when using constant stimulations is needed.
KW - FMRI
KW - Habituation
KW - Hemodynamic response
KW - Median nerve stimulation
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U2 - 10.1016/j.mri.2012.10.012
DO - 10.1016/j.mri.2012.10.012
M3 - Article
C2 - 23228312
AN - SCOPUS:84876135255
SN - 0730-725X
VL - 31
SP - 550
EP - 554
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
IS - 4
ER -