Functional models for mononuclear nonheme iron enzymes

Jan Uwe Rohde, Michael R. Bukowski, Lawrence Que

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


Increasing interest in mononuclear nonheme iron enzymes that activate dioxygen has resulted in an explosion of information on such enzymes in recent years. Concomitantly, efforts to model the active sites of these enzymes have produced synthetic complexes capable of mimicking some aspect of the reactivity of the metal center in several enzymes. These functional models carry out oxidative transformations analogous to those catalyzed by the enzymes and in some cases allow iron(III)-peroxo or iron(IV)-oxo intermediates to be trapped and characterized.

Original languageEnglish (US)
Pages (from-to)674-682
Number of pages9
JournalCurrent opinion in chemical biology
Issue number6
StatePublished - Dec 2003

Bibliographical note

Funding Information:
The work from the Que laboratory described in this review was supported by the National Institutes of Health (GM-33162 and GM-38767).


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