TY - JOUR
T1 - Functional models for iron-bleomycin
AU - Roelfes, Gerard
AU - Lubben, Marcel
AU - Leppard, Simon W.
AU - Schudde, Ebe P.
AU - Hermant, Roel M.
AU - Hage, Ronald
AU - Wilkinson, Elizabeth C.
AU - Que, Larry
AU - Feringa, Ben L.
N1 - Funding Information:
Financial support of Unilever Research, Vlaardingen and the National Institutes of Health (GM-33162) is gratefully acknowledged.
PY - 1997/3/14
Y1 - 1997/3/14
N2 - A new pentadentate ligand, N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine (N4Py), has been prepared. The corresponding iron(II) complex, [N4PyFe(CH3CN)](ClO4)2, serves as a functional model for the active site of ironbleomycin. Upon treatment with H2O2 the formation of a purple intermediate has been observed, which has been characterized as an iron(III)-hydroperoxide complex. This N4Py-iron-hydroperoxide system has proven to be an active oxidation catalyst.
AB - A new pentadentate ligand, N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine (N4Py), has been prepared. The corresponding iron(II) complex, [N4PyFe(CH3CN)](ClO4)2, serves as a functional model for the active site of ironbleomycin. Upon treatment with H2O2 the formation of a purple intermediate has been observed, which has been characterized as an iron(III)-hydroperoxide complex. This N4Py-iron-hydroperoxide system has proven to be an active oxidation catalyst.
KW - Hydroperoxide compounds
KW - Nonheme iron compounds
KW - Oxygen activation
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U2 - 10.1016/S1381-1169(96)00356-1
DO - 10.1016/S1381-1169(96)00356-1
M3 - Article
AN - SCOPUS:0030938770
SN - 1381-1169
VL - 117
SP - 223
EP - 227
JO - Journal of Molecular Catalysis A: Chemical
JF - Journal of Molecular Catalysis A: Chemical
IS - 1-3
ER -