Functional models for iron-bleomycin

Gerard Roelfes, Marcel Lubben, Simon W. Leppard, Ebe P. Schudde, Roel M. Hermant, Ronald Hage, Elizabeth C. Wilkinson, Larry Que, Ben L. Feringa

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

A new pentadentate ligand, N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine (N4Py), has been prepared. The corresponding iron(II) complex, [N4PyFe(CH3CN)](ClO4)2, serves as a functional model for the active site of ironbleomycin. Upon treatment with H2O2 the formation of a purple intermediate has been observed, which has been characterized as an iron(III)-hydroperoxide complex. This N4Py-iron-hydroperoxide system has proven to be an active oxidation catalyst.

Original languageEnglish (US)
Pages (from-to)223-227
Number of pages5
JournalJournal of Molecular Catalysis A: Chemical
Volume117
Issue number1-3
DOIs
StatePublished - Mar 14 1997

Bibliographical note

Funding Information:
Financial support of Unilever Research, Vlaardingen and the National Institutes of Health (GM-33162) is gratefully acknowledged.

Keywords

  • Hydroperoxide compounds
  • Nonheme iron compounds
  • Oxygen activation

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