Functional magnetic resonance imaging with intermolecular multiple- quantum coherences

Wolfgang Richter, Marlene Richter, Warren S. Warren, Hellmut Merkle, Peter Andersen, Gregor Adriany, Kamil Ugurbil

Research output: Contribution to journalArticle

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For the first time, we demonstrate here functional magnetic resonance imaging (fMRI) using intermolecular multiple-quantum coherences (iMQCs). iMQCs are normally not observed in liquid-state NMR because dipolar interactions between spins average to zero. If the magnetic isotropy of the sample is broken through the use of magnetic field gradients, dipolar couplings can reappear, and hence iMQCs can be observed. Conventional (BOLD) fMRI measures susceptibility variations averaged over each voxel. In the experiment performed here, the sensitivity of iMQCs to frequency variations over mesoscopic and well-defined distances is exploited. We show that iMQC contrast is qualitatively and quantitatively different from BOLD contrast in a visual stimulation task. While the number of activated pixels is smaller in iMQC contrast, the intensity change in some pixels exceeds that of BOLD contrast severalfold. (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)489-494
Number of pages6
JournalMagnetic Resonance Imaging
Issue number5
StatePublished - Jun 1 2000



  • Brain function
  • Intermolecular multiple quantum coherences
  • fMRI

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