The current technical and methodological status of functional magnetic resonance imaging (fMRI) is reviewed. The mechanisms underlying the effects of deoxyhemoglobin concentration and cerebral blood flow changes are discussed, and methods for monitoring these changes are described and compared. Methods for post-processing fMRI data are outlined. Potential problems and solutions related to vessels and motion are discussed in detail.
Bibliographical noteFunding Information:
Authors thank many collaborators, especially Drs Seiji Ogawa, Ravi Menon, and Xiaoping Hu. We also thank Drs Peter Erhard, Wei Chen and Wolfgang Richter for stimulating discussion, John Strupp for his fMRI processing software STIMULATE, Peter Andersen, Gregor Adriany and Hellmut Merkle for their excellent hardware support, and Frank Crosby for proof-reading. This work was supported in part by NIH grants RR08079, NS32919 and NS32437, and a Grant-in-Aid from the University of Minnesota.
- Brain mapping
- Cortical mapping
- Functional MRI
- Functional imaging