Functional interleukin-2 receptors are expressed on natural killer-like leukemic cells from a dog with cutaneous lymphoma

S. C. Helfand, J. F. Modiano, P. F. Moore, S. A. Soergel, P. S. MacWilliams, R. D. Dubielzig, J. A. Hank, E. W. Gelfand, P. M. Sondel

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We identified a dog with large granular lymphocytic leukemia and cutaneous lymphoma that exhibited constitutive expression of interleukin-2 (IL-2) receptors by the leukemic peripheral blood lymphocytes. The leukemic cells phenotypically resembled natural killer (NK) cells, and their surface IL-2 receptors were functional, as determined by the capacity to bind human recombinant IL-2 with high-affinity resulting in the transduction of proliferation signals and in the development of lymphokine-activated killer cell activity. These cells produced IL-2 spontaneously, and they may have maintained their proliferative state through an IL-2-dependent autocrine growth pathway. Our results indicate that neoplastic lymphocytes of syndromes that involve circulating leukemic cells with dermotropism can originate from NK-like cells. Additionally, the data also suggest that proliferative conditions such as these may be the result of the aberrant production of IL- 2. Further, this case illustrates the potential for the use of hematopoietic malignancies in the dog as a suitable animal model for immune targeting of IL-2 receptors as a novel treatment approach for similar malignancies of human beings.

Original languageEnglish (US)
Pages (from-to)636-645
Number of pages10
JournalBlood
Volume86
Issue number2
StatePublished - Jan 1 1995

Fingerprint

Interleukin-2 Receptors
Interleukin-2
Lymphoma
Dogs
Skin
Lymphocytes
Natural Killer Cells
Large Granular Lymphocytic Leukemia
Lymphokine-Activated Killer Cells
Lymphokines
Hematologic Neoplasms
Signal Transduction
Animals
Blood
Animal Models
Growth
Neoplasms
Therapeutics

Cite this

Helfand, S. C., Modiano, J. F., Moore, P. F., Soergel, S. A., MacWilliams, P. S., Dubielzig, R. D., ... Sondel, P. M. (1995). Functional interleukin-2 receptors are expressed on natural killer-like leukemic cells from a dog with cutaneous lymphoma. Blood, 86(2), 636-645.

Functional interleukin-2 receptors are expressed on natural killer-like leukemic cells from a dog with cutaneous lymphoma. / Helfand, S. C.; Modiano, J. F.; Moore, P. F.; Soergel, S. A.; MacWilliams, P. S.; Dubielzig, R. D.; Hank, J. A.; Gelfand, E. W.; Sondel, P. M.

In: Blood, Vol. 86, No. 2, 01.01.1995, p. 636-645.

Research output: Contribution to journalArticle

Helfand, SC, Modiano, JF, Moore, PF, Soergel, SA, MacWilliams, PS, Dubielzig, RD, Hank, JA, Gelfand, EW & Sondel, PM 1995, 'Functional interleukin-2 receptors are expressed on natural killer-like leukemic cells from a dog with cutaneous lymphoma', Blood, vol. 86, no. 2, pp. 636-645.
Helfand SC, Modiano JF, Moore PF, Soergel SA, MacWilliams PS, Dubielzig RD et al. Functional interleukin-2 receptors are expressed on natural killer-like leukemic cells from a dog with cutaneous lymphoma. Blood. 1995 Jan 1;86(2):636-645.
Helfand, S. C. ; Modiano, J. F. ; Moore, P. F. ; Soergel, S. A. ; MacWilliams, P. S. ; Dubielzig, R. D. ; Hank, J. A. ; Gelfand, E. W. ; Sondel, P. M. / Functional interleukin-2 receptors are expressed on natural killer-like leukemic cells from a dog with cutaneous lymphoma. In: Blood. 1995 ; Vol. 86, No. 2. pp. 636-645.
@article{74eec983fba64e25a136376a3a92580e,
title = "Functional interleukin-2 receptors are expressed on natural killer-like leukemic cells from a dog with cutaneous lymphoma",
abstract = "We identified a dog with large granular lymphocytic leukemia and cutaneous lymphoma that exhibited constitutive expression of interleukin-2 (IL-2) receptors by the leukemic peripheral blood lymphocytes. The leukemic cells phenotypically resembled natural killer (NK) cells, and their surface IL-2 receptors were functional, as determined by the capacity to bind human recombinant IL-2 with high-affinity resulting in the transduction of proliferation signals and in the development of lymphokine-activated killer cell activity. These cells produced IL-2 spontaneously, and they may have maintained their proliferative state through an IL-2-dependent autocrine growth pathway. Our results indicate that neoplastic lymphocytes of syndromes that involve circulating leukemic cells with dermotropism can originate from NK-like cells. Additionally, the data also suggest that proliferative conditions such as these may be the result of the aberrant production of IL- 2. Further, this case illustrates the potential for the use of hematopoietic malignancies in the dog as a suitable animal model for immune targeting of IL-2 receptors as a novel treatment approach for similar malignancies of human beings.",
author = "Helfand, {S. C.} and Modiano, {J. F.} and Moore, {P. F.} and Soergel, {S. A.} and MacWilliams, {P. S.} and Dubielzig, {R. D.} and Hank, {J. A.} and Gelfand, {E. W.} and Sondel, {P. M.}",
year = "1995",
month = "1",
day = "1",
language = "English (US)",
volume = "86",
pages = "636--645",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "2",

}

TY - JOUR

T1 - Functional interleukin-2 receptors are expressed on natural killer-like leukemic cells from a dog with cutaneous lymphoma

AU - Helfand, S. C.

AU - Modiano, J. F.

AU - Moore, P. F.

AU - Soergel, S. A.

AU - MacWilliams, P. S.

AU - Dubielzig, R. D.

AU - Hank, J. A.

AU - Gelfand, E. W.

AU - Sondel, P. M.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - We identified a dog with large granular lymphocytic leukemia and cutaneous lymphoma that exhibited constitutive expression of interleukin-2 (IL-2) receptors by the leukemic peripheral blood lymphocytes. The leukemic cells phenotypically resembled natural killer (NK) cells, and their surface IL-2 receptors were functional, as determined by the capacity to bind human recombinant IL-2 with high-affinity resulting in the transduction of proliferation signals and in the development of lymphokine-activated killer cell activity. These cells produced IL-2 spontaneously, and they may have maintained their proliferative state through an IL-2-dependent autocrine growth pathway. Our results indicate that neoplastic lymphocytes of syndromes that involve circulating leukemic cells with dermotropism can originate from NK-like cells. Additionally, the data also suggest that proliferative conditions such as these may be the result of the aberrant production of IL- 2. Further, this case illustrates the potential for the use of hematopoietic malignancies in the dog as a suitable animal model for immune targeting of IL-2 receptors as a novel treatment approach for similar malignancies of human beings.

AB - We identified a dog with large granular lymphocytic leukemia and cutaneous lymphoma that exhibited constitutive expression of interleukin-2 (IL-2) receptors by the leukemic peripheral blood lymphocytes. The leukemic cells phenotypically resembled natural killer (NK) cells, and their surface IL-2 receptors were functional, as determined by the capacity to bind human recombinant IL-2 with high-affinity resulting in the transduction of proliferation signals and in the development of lymphokine-activated killer cell activity. These cells produced IL-2 spontaneously, and they may have maintained their proliferative state through an IL-2-dependent autocrine growth pathway. Our results indicate that neoplastic lymphocytes of syndromes that involve circulating leukemic cells with dermotropism can originate from NK-like cells. Additionally, the data also suggest that proliferative conditions such as these may be the result of the aberrant production of IL- 2. Further, this case illustrates the potential for the use of hematopoietic malignancies in the dog as a suitable animal model for immune targeting of IL-2 receptors as a novel treatment approach for similar malignancies of human beings.

UR - http://www.scopus.com/inward/record.url?scp=0029020241&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029020241&partnerID=8YFLogxK

M3 - Article

VL - 86

SP - 636

EP - 645

JO - Blood

JF - Blood

SN - 0006-4971

IS - 2

ER -