Functional innervation of the striatum by ventral mesencephalic grafts in mice with inherited nigrostriatal dopamine deficiency

Walter C. Low, Lazaros C. Triarhou, Yumiko Kaseda, James Norton, Bernardino Ghetti

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Weaver mutant mice are characterized by a decrease in striatal dopamine (DA), which is associated with a progressive loss of DA neurones in the substantia nigra. This mutant thus provides the opportunity to examine the functional effects of DA neurones grafted to the striatum in a genetic model of parkinsonism. Ventral mesencephalic tissue from normal foetuses was placed on the surface of the right dorsal striatum of adult weaver mutants. After grafting, animals were tested for methamphetamine-induced circling behaviour. Mutants with DA containing grafts displayed a significant circling bias toward the left, non-grafted side. Mutants without grafts did not display any rotational bias to either side. These results demonstrate that grafted DA containing neurones establish a functional innervation of the weaver striatum and suggest that grafting of neural tissue is a viable approach in restoring function in genetic degenerative disorders of the nigrostriatal system.

Original languageEnglish (US)
Pages (from-to)315-321
Number of pages7
JournalBrain Research
Volume435
Issue number1-2
DOIs
StatePublished - Dec 1 1987

Keywords

  • Dopamine
  • Functional recovery
  • Nigral transplant
  • Parkinson disease
  • Rotational behavior
  • Striatum
  • Weaver mutant mouse

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