Functional Imaging in Clinical Assessment? The Rise of Neurodiagnostics with fMRI

Angus MacDonald, Jessica A H Jones

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    This article provides an update on progress in the use of neuroimaging for predicting clinical states, with particular attention to diagnosis. It discusses the underpinnings of the blood oxygenation level-dependent response used in fMRI, as well as issues involved in measuring this signal reliably. The article then considers the logic underpinning the development of models based on brain data to examine latent states, such as deception, and latent traits, such as the diagnosis of schizophrenia. It concludes that neuroimaging, while not currently a practical tool for clinical assessment, is likely to provide an important avenue of new ideas. Biomarkers, such as those derived from neuroimaging, are likely to have a role in understanding dimensionality and the common origins of certain disorders (for example, depression and anxiety) by providing biological principles around which to organize thinking in these areas.

    Original languageEnglish (US)
    Title of host publicationOxford Handbook of Personality Assessment
    PublisherOxford University Press
    ISBN (Electronic)9780199940592
    ISBN (Print)9780195366877
    DOIs
    StatePublished - Sep 18 2012

    Fingerprint

    Neuroimaging
    Magnetic Resonance Imaging
    Deception
    Schizophrenia
    Anxiety
    Biomarkers
    Depression
    Brain
    Thinking

    Keywords

    • Biomarkers
    • Blood oxygenation level
    • Clinical assessment
    • Deception
    • Diagnosis
    • fMRI
    • Latent states
    • Latent traits
    • Schizophrenia

    Cite this

    MacDonald, A., & Jones, J. A. H. (2012). Functional Imaging in Clinical Assessment? The Rise of Neurodiagnostics with fMRI. In Oxford Handbook of Personality Assessment Oxford University Press. https://doi.org/10.1093/oxfordhb/9780195366877.013.0019

    Functional Imaging in Clinical Assessment? The Rise of Neurodiagnostics with fMRI. / MacDonald, Angus; Jones, Jessica A H.

    Oxford Handbook of Personality Assessment. Oxford University Press, 2012.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    MacDonald, Angus ; Jones, Jessica A H. / Functional Imaging in Clinical Assessment? The Rise of Neurodiagnostics with fMRI. Oxford Handbook of Personality Assessment. Oxford University Press, 2012.
    @inbook{2c109d114a37422fa4eae8b054813086,
    title = "Functional Imaging in Clinical Assessment? The Rise of Neurodiagnostics with fMRI",
    abstract = "This article provides an update on progress in the use of neuroimaging for predicting clinical states, with particular attention to diagnosis. It discusses the underpinnings of the blood oxygenation level-dependent response used in fMRI, as well as issues involved in measuring this signal reliably. The article then considers the logic underpinning the development of models based on brain data to examine latent states, such as deception, and latent traits, such as the diagnosis of schizophrenia. It concludes that neuroimaging, while not currently a practical tool for clinical assessment, is likely to provide an important avenue of new ideas. Biomarkers, such as those derived from neuroimaging, are likely to have a role in understanding dimensionality and the common origins of certain disorders (for example, depression and anxiety) by providing biological principles around which to organize thinking in these areas.",
    keywords = "Biomarkers, Blood oxygenation level, Clinical assessment, Deception, Diagnosis, fMRI, Latent states, Latent traits, Schizophrenia",
    author = "Angus MacDonald and Jones, {Jessica A H}",
    year = "2012",
    month = "9",
    day = "18",
    doi = "10.1093/oxfordhb/9780195366877.013.0019",
    language = "English (US)",
    isbn = "9780195366877",
    booktitle = "Oxford Handbook of Personality Assessment",
    publisher = "Oxford University Press",
    address = "United States",

    }

    TY - CHAP

    T1 - Functional Imaging in Clinical Assessment? The Rise of Neurodiagnostics with fMRI

    AU - MacDonald, Angus

    AU - Jones, Jessica A H

    PY - 2012/9/18

    Y1 - 2012/9/18

    N2 - This article provides an update on progress in the use of neuroimaging for predicting clinical states, with particular attention to diagnosis. It discusses the underpinnings of the blood oxygenation level-dependent response used in fMRI, as well as issues involved in measuring this signal reliably. The article then considers the logic underpinning the development of models based on brain data to examine latent states, such as deception, and latent traits, such as the diagnosis of schizophrenia. It concludes that neuroimaging, while not currently a practical tool for clinical assessment, is likely to provide an important avenue of new ideas. Biomarkers, such as those derived from neuroimaging, are likely to have a role in understanding dimensionality and the common origins of certain disorders (for example, depression and anxiety) by providing biological principles around which to organize thinking in these areas.

    AB - This article provides an update on progress in the use of neuroimaging for predicting clinical states, with particular attention to diagnosis. It discusses the underpinnings of the blood oxygenation level-dependent response used in fMRI, as well as issues involved in measuring this signal reliably. The article then considers the logic underpinning the development of models based on brain data to examine latent states, such as deception, and latent traits, such as the diagnosis of schizophrenia. It concludes that neuroimaging, while not currently a practical tool for clinical assessment, is likely to provide an important avenue of new ideas. Biomarkers, such as those derived from neuroimaging, are likely to have a role in understanding dimensionality and the common origins of certain disorders (for example, depression and anxiety) by providing biological principles around which to organize thinking in these areas.

    KW - Biomarkers

    KW - Blood oxygenation level

    KW - Clinical assessment

    KW - Deception

    KW - Diagnosis

    KW - fMRI

    KW - Latent states

    KW - Latent traits

    KW - Schizophrenia

    UR - http://www.scopus.com/inward/record.url?scp=84923627550&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84923627550&partnerID=8YFLogxK

    U2 - 10.1093/oxfordhb/9780195366877.013.0019

    DO - 10.1093/oxfordhb/9780195366877.013.0019

    M3 - Chapter

    SN - 9780195366877

    BT - Oxford Handbook of Personality Assessment

    PB - Oxford University Press

    ER -