Functional connectivity targeting for deep brain stimulation in essential tremor

Jeffrey S. Anderson, H. S. Dhatt, M. A. Ferguson, M. Lopez-Larson, L. E. Schrock, P. A. House, D. Yurgelun-Todd

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


BACKGROUND AND PURPOSE: Deep brain stimulation of the thalamus has become a valuable treatment for medication-refractory essential tremor, but current targeting provides only a limited ability to account for individual anatomic variability. We examined whether functional connectivity measurements among the motor cortex, superior cerebellum, and thalamus would allow discrimination of precise targets useful for image guidance of neurostimulator placement. MATERIALS AND METHODS: Resting BOLD images (8 minutes) were obtained in 58 healthy adolescent and adult volunteers. Regions of interest were identified from an anatomic atlas and a finger movement task in each subject in the primary motor cortex and motor activation region of the bilateral superior cerebellum. Correlation was measured in the time series of each thalamic voxel with the 4 seeds. An analogous procedure was performed on a single subject imaged for 10 hours to constrain the time needed for single-subject optimization of thalamic targets. RESULTS: Mean connectivity images from 58 subjects showed precisely localized targets within the expected location of the ventral intermediate nucleus of the thalamus, within a single voxel of currently used deep brain stimulation anatomic targets. These targets could be mapped with single-voxel accuracy in a single subject with 3 hours of imaging time, though targets were reproduced in different locations for the individual than for the group averages. CONCLUSIONS: Interindividual variability likely exists in optimal placement for thalamic deep brain stimulation targeting of the cerebellar thalamus for essential tremor. Individualized thalamic targets can be precisely estimated for image guidance with sufficient imaging time.

Original languageEnglish (US)
Pages (from-to)1963-1968
Number of pages6
JournalAmerican Journal of Neuroradiology
Issue number10
StatePublished - Nov 2011


Dive into the research topics of 'Functional connectivity targeting for deep brain stimulation in essential tremor'. Together they form a unique fingerprint.

Cite this