Functional comparison of innate immune signaling pathways in primates

Luis B. Barreiro, John C. Marioni, Ran Blekhman, Matthew Stephens, Yoav Gilad

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Humans respond differently than other primates to a large number of infections. Differences in susceptibility to infectious agents between humans and other primates are probably due to inter-species differences in immune response to infection. Consistent with that notion, genes involved in immunity-related processes are strongly enriched among recent targets of positive selection in primates, suggesting that immune responses evolve rapidly, yet providing only indirect evidence for possible inter-species functional differences. To directly compare immune responses among primates, we stimulated primary monocytes from humans, chimpanzees, and rhesus macaques with lipopolysaccharide (LPS) and studied the ensuing time-course regulatory responses. We find that, while the universal Toll-like receptor response is mostly conserved across primates, the regulatory response associated with viral infections is often lineage-specific, probably reflecting rapid host-virus mutual adaptation cycles. Additionally, human-specific immune responses are enriched for genes involved in apoptosis, as well as for genes associated with cancer and with susceptibility to infectious diseases or immune-related disorders. Finally, we find that chimpanzee-specific immune signaling pathways are enriched for HIV-interacting genes. Put together, our observations lend strong support to the notion that lineage-specific immune responses may help explain known inter-species differences in susceptibility to infectious diseases.

Original languageEnglish (US)
Article numbere1001249
Pages (from-to)1-13
Number of pages13
JournalPLoS genetics
Volume6
Issue number12
DOIs
StatePublished - Dec 2010

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    Barreiro, L. B., Marioni, J. C., Blekhman, R., Stephens, M., & Gilad, Y. (2010). Functional comparison of innate immune signaling pathways in primates. PLoS genetics, 6(12), 1-13. [e1001249]. https://doi.org/10.1371/journal.pgen.1001249