Functional alterations in non-T cells in rheumatic heart disease

E. D. Gray, W. E. Regelmann, L. W. Wannamaker, A. El Kholy, Z. H. Abdin

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The mediation of the T cell lymphoproliferative response to streptococcal blastogen A by non-T mononuclear cells was studied in patients with rheumatic heart disease (RHD) and control subjects. Non-T cells are essential for T cell response to blastogen A. Non-T cells from RHD patients were less effective in enabling the T lymphocyte response to blastogen A than control non-T cells though no consistent difference was observed in the response to phytohaemagglutinin. The results suggest that a functional alteration is present in the non-T cells from RHD patients which might be related to the pathogenesis of the disease.

Original languageEnglish (US)
Pages (from-to)488-492
Number of pages5
JournalClinical and Experimental Immunology
Volume49
Issue number2
StatePublished - Oct 5 1982

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