Frontal white matter microstructure and treatment response of late-life depression: A preliminary study

George S. Alexopoulos, Dimitris N. Kiosses, Steven J. Choi, Christopher F. Murphy, Kelvin O. Lim

Research output: Contribution to journalArticlepeer-review

262 Scopus citations

Abstract

Objective: This study tested the hypothesis that microstructural abnormalities in white matter areas of the brain containing frontostriatal tracts are associated with a low rate of remission of geriatric depression. Method: Thirteen older patients with major depression received open, but controlled, treatment with citalopram at a target daily dose of 40 mg for 12 weeks. Diffusion tensor imaging was used to determine fractional anisotropy in preselected white matter regions. Results: Survival analysis with Cox's proportional hazards model revealed that lower fractional anisotropy of the right and the left frontal white matter regions 15 mm above the anterior commissure-posterior commissure plane was associated with a low remission rate after age was considered. Remission was not significantly associated with fractional anisotropy of lower frontal regions or a temporal region. Conclusions: Microstructural white matter abnormalities lateral to the anterior cingulate may be associated with a low rate of remission of geriatric depression.

Original languageEnglish (US)
Pages (from-to)1929-1932
Number of pages4
JournalAmerican Journal of Psychiatry
Volume159
Issue number11
DOIs
StatePublished - Nov 1 2002

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