From the ECM to the cytoskeleton and back: How integrins orchestrate T cell action

J. A. Epler, R. Liu, Yoji Shimizu

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

T lymphocytes constitute a highly dynamic tissue type. During the course of their lives, they travel through a variety of physiological environments and experience a multitude of interactions with extracellular matrix components and other cells. In order to do this, they must receive many environmental cues, and translate these signals into the appropriate biological actions. Particularly dramatic are the cytoskeletal shape changes a T cell must undergo during the processes of leaving the bloodstream, migrating through tissues, and encountering antigen. In this review, we highlight the role of integrins in providing a link between the extracellular environment and cytoskeletal regulation and how these receptors help to orchestrate T cell migration and antigen recognition.

Original languageEnglish (US)
Pages (from-to)155-170
Number of pages16
JournalDevelopmental Immunology
Volume7
Issue number2-4
DOIs
StatePublished - 2000

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