From Microscale Devices to 3D Printing: Advances in Fabrication of 3D Cardiovascular Tissues

Anton V. Borovjagin, Brenda M. Ogle, Joel L. Berry, Jianyi Zhang

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Current strategies for engineering cardiovascular cells and tissues have yielded a variety of sophisticated tools for studying disease mechanisms, for development of drug therapies, and for fabrication of tissue equivalents that may have application in future clinical use. These efforts are motivated by the need to extend traditional 2-dimensional (2D) cell culture systems into 3D to more accurately replicate in vivo cell and tissue function of cardiovascular structures. Developments in microscale devices and bioprinted 3D tissues are beginning to supplant traditional 2D cell cultures and preclinical animal studies that have historically been the standard for drug and tissue development. These new approaches lend themselves to patient-specific diagnostics, therapeutics, and tissue regeneration. The emergence of these technologies also carries technical challenges to be met before traditional cell culture and animal testing become obsolete. Successful development and validation of 3D human tissue constructs will provide powerful new paradigms for more cost effective and timely translation of cardiovascular tissue equivalents.

Original languageEnglish (US)
Pages (from-to)150-165
Number of pages16
JournalCirculation research
Volume120
Issue number1
DOIs
StatePublished - Jan 6 2017

Fingerprint

Equipment and Supplies
Cell Culture Techniques
Cell Engineering
Tissue Engineering
Three Dimensional Printing
Regeneration
Technology
Costs and Cost Analysis
Drug Therapy
Pharmaceutical Preparations
Therapeutics

Keywords

  • biocompatible materials
  • heart
  • printing, three-dimensional
  • stem cells
  • tissue engineering

Cite this

From Microscale Devices to 3D Printing : Advances in Fabrication of 3D Cardiovascular Tissues. / Borovjagin, Anton V.; Ogle, Brenda M.; Berry, Joel L.; Zhang, Jianyi.

In: Circulation research, Vol. 120, No. 1, 06.01.2017, p. 150-165.

Research output: Contribution to journalReview article

Borovjagin, Anton V. ; Ogle, Brenda M. ; Berry, Joel L. ; Zhang, Jianyi. / From Microscale Devices to 3D Printing : Advances in Fabrication of 3D Cardiovascular Tissues. In: Circulation research. 2017 ; Vol. 120, No. 1. pp. 150-165.
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