From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility

Lorene M. Lanier, Frank B. Gertler

Research output: Contribution to journalReview articlepeer-review

173 Scopus citations

Abstract

The Abl tyrosine kinase plays an important role in axonogenesis. Recent reports indicate that this role involves interaction with several different protein families, including LAR phosphatases, catenin/cadherin cell adhesion complexes, Trio family GEFs, and Ena/VASP family actin regulatory proteins. These findings suggest that Abl and its associated proteins may regulate cell adhesion and actin polymerization, thereby regulating growth cone motility during axonogenesis.

Original languageEnglish (US)
Pages (from-to)80-87
Number of pages8
JournalCurrent opinion in neurobiology
Volume10
Issue number1
DOIs
StatePublished - Feb 1 2000

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