The Abl tyrosine kinase plays an important role in axonogenesis. Recent reports indicate that this role involves interaction with several different protein families, including LAR phosphatases, catenin/cadherin cell adhesion complexes, Trio family GEFs, and Ena/VASP family actin regulatory proteins. These findings suggest that Abl and its associated proteins may regulate cell adhesion and actin polymerization, thereby regulating growth cone motility during axonogenesis.
Bibliographical noteFunding Information:
Because of space constraints, we were not able to cover all work in this area as comprehensively as we would have liked. We thank Eric Liebl and David Van Vactor for sharing their unpublished observations and Paul Garrity, David Van Vactor and members of the Gertler laboratory for their comments and suggestions on the manuscript. LM Lanier is supported by National Institutes of Health postdoctoral fellowship #NS10655, and work in FB Gerther’s laboratory is supported by National Institute of General Medical Science grant #GM58801.