Frizzled fissure to improve central nervous system drug delivery?

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Delivery of therapeutics to the brain is challenging because of efflux pumps located in the vascular endothelium. A detailed analysis of Wnt signaling in a human brain endothelial cell line indicates that expression and function of P-glycoprotein, a major efflux transporter, is controlled by non-canonical Wnt signaling. Inhibition of this pathway leads to downregulation of P-glycoprotein and increased transcellular drug transport and reveals a potential strategy for improving drug delivery for treatment of neurologic diseases.

Original languageEnglish (US)
Pages (from-to)1257
Number of pages1
JournalJournal of Cerebral Blood Flow and Metabolism
Volume34
Issue number8
DOIs
StatePublished - Aug 2014

Keywords

  • P-glycoprotein
  • Wnt signaling
  • blood-brain transport
  • drug delivery
  • neurovascular unit
  • transporter

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