Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus

Jenna R. Rosinski; Lauren E. Raasch; Patrick Barros Tiburcio; Meghan E. Breitbach; Phoenix M. Shepherd; Keisuke Yamamoto; Elaina Razo; Nicholas P. Krabbe; Mason I. Bliss; Alexander D. Richardson; Morgan A. Einwalter; Andrea M. Weiler; Emily L. Sneed; Kerri B. Fuchs; Xiankun Zeng; Kevin K. Noguchi; Terry K. Morgan; Alexandra J. Alberts; Kathleen M. Antony; Sabrina Kabakov; Karla K. Ausderau; Ellie K. Bohm; Julia C. Pritchard; Rachel V. Spanton; James N. Ver Hoove; Charlene B.Y. Kim; T. Michael Nork; Alex W. Katz; Carol A. Rasmussen; Amy Hartman; Andres Mejia; Puja Basu; Heather A. Simmons; Jens C. Eickhoff; Thomas C. Friedrich; Matthew T. Aliota; Emma L. Mohr; Dawn M. Dudley; David H. O’Connor; Christina M. Newman

doi:10.1371/journal.ppat.1011282

Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus

Jenna R. Rosinski
, Lauren E. Raasch
, Patrick Barros Tiburcio
, Meghan E. Breitbach
, Phoenix M. Shepherd
, Keisuke Yamamoto
, Elaina Razo
, Nicholas P. Krabbe
, Mason I. Bliss
, Alexander D. Richardson
, Morgan A. Einwalter
, Andrea M. Weiler
, Emily L. Sneed
, Kerri B. Fuchs
, Xiankun Zeng
, Kevin K. Noguchi
, Terry K. Morgan
, Alexandra J. Alberts
, Kathleen M. Antony
, Sabrina Kabakov

Karla K. Ausderau, Ellie K. Bohm, Julia C. Pritchard, Rachel V. Spanton, James N. Ver Hoove, Charlene B.Y. Kim, T. Michael Nork, Alex W. Katz, Carol A. Rasmussen, Amy Hartman, Andres Mejia, Puja Basu, Heather A. Simmons, Jens C. Eickhoff, Thomas C. Friedrich, Matthew T. Aliota, Emma L. Mohr, Dawn M. Dudley, David H. O’Connor, Christina M. Newman

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about the impacts of gestational African-lineage ZIKV infections. Given high human immunodeficiency virus (HIV) burdens in regions where African-lineage ZIKV circulates, we evaluated whether pregnant rhesus macaques infected with simian immunodeficiency virus (SIV) have a higher risk of African-lineage ZIKV-associated birth defects. Remarkably, in both SIV+ and SIV- animals, ZIKV infection early in the first trimester caused a high incidence (78%) of spontaneous pregnancy loss within 20 days. These findings suggest a significant risk for early pregnancy loss associated with African-lineage ZIKV infection and provide the first consistent ZIKV-associated phenotype in macaques for testing medical countermeasures.

Original language	English (US)
Article number	e1011282
Journal	PLoS pathogens
Volume	19
Issue number	3
DOIs	https://doi.org/10.1371/journal.ppat.1011282
State	Published - Mar 2023

Bibliographical note

Publisher Copyright:
This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Rosinski, J. R., Raasch, L. E., Tiburcio, P. B., Breitbach, M. E., Shepherd, P. M., Yamamoto, K., Razo, E., Krabbe, N. P., Bliss, M. I., Richardson, A. D., Einwalter, M. A., Weiler, A. M., Sneed, E. L., Fuchs, K. B., Zeng, X., Noguchi, K. K., Morgan, T. K., Alberts, A. J., Antony, K. M., ... Newman, C. M. (2023). Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus. PLoS pathogens, 19(3), Article e1011282. https://doi.org/10.1371/journal.ppat.1011282

Rosinski, JR, Raasch, LE, Tiburcio, PB, Breitbach, ME, Shepherd, PM, Yamamoto, K, Razo, E, Krabbe, NP, Bliss, MI, Richardson, AD, Einwalter, MA, Weiler, AM, Sneed, EL, Fuchs, KB, Zeng, X, Noguchi, KK, Morgan, TK, Alberts, AJ, Antony, KM, Kabakov, S, Ausderau, KK, Bohm, EK, Pritchard, JC, Spanton, RV, Ver Hoove, JN, Kim, CBY, Nork, TM, Katz, AW, Rasmussen, CA, Hartman, A, Mejia, A, Basu, P, Simmons, HA, Eickhoff, JC, Friedrich, TC, Aliota, MT, Mohr, EL, Dudley, DM, O’Connor, DH & Newman, CM 2023, 'Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus', PLoS pathogens, vol. 19, no. 3, e1011282. https://doi.org/10.1371/journal.ppat.1011282

@article{0b9ceb711f3b4c24b9e753207d1f66df,

title = "Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus",

abstract = "In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about the impacts of gestational African-lineage ZIKV infections. Given high human immunodeficiency virus (HIV) burdens in regions where African-lineage ZIKV circulates, we evaluated whether pregnant rhesus macaques infected with simian immunodeficiency virus (SIV) have a higher risk of African-lineage ZIKV-associated birth defects. Remarkably, in both SIV+ and SIV- animals, ZIKV infection early in the first trimester caused a high incidence (78\%) of spontaneous pregnancy loss within 20 days. These findings suggest a significant risk for early pregnancy loss associated with African-lineage ZIKV infection and provide the first consistent ZIKV-associated phenotype in macaques for testing medical countermeasures.",

author = "Rosinski, \{Jenna R.\} and Raasch, \{Lauren E.\} and Tiburcio, \{Patrick Barros\} and Breitbach, \{Meghan E.\} and Shepherd, \{Phoenix M.\} and Keisuke Yamamoto and Elaina Razo and Krabbe, \{Nicholas P.\} and Bliss, \{Mason I.\} and Richardson, \{Alexander D.\} and Einwalter, \{Morgan A.\} and Weiler, \{Andrea M.\} and Sneed, \{Emily L.\} and Fuchs, \{Kerri B.\} and Xiankun Zeng and Noguchi, \{Kevin K.\} and Morgan, \{Terry K.\} and Alberts, \{Alexandra J.\} and Antony, \{Kathleen M.\} and Sabrina Kabakov and Ausderau, \{Karla K.\} and Bohm, \{Ellie K.\} and Pritchard, \{Julia C.\} and Spanton, \{Rachel V.\} and \{Ver Hoove\}, \{James N.\} and Kim, \{Charlene B.Y.\} and Nork, \{T. Michael\} and Katz, \{Alex W.\} and Rasmussen, \{Carol A.\} and Amy Hartman and Andres Mejia and Puja Basu and Simmons, \{Heather A.\} and Eickhoff, \{Jens C.\} and Friedrich, \{Thomas C.\} and Aliota, \{Matthew T.\} and Mohr, \{Emma L.\} and Dudley, \{Dawn M.\} and O{\textquoteright}Connor, \{David H.\} and Newman, \{Christina M.\}",

note = "Publisher Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.",

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AU - Raasch, Lauren E.

AU - Tiburcio, Patrick Barros

AU - Breitbach, Meghan E.

AU - Shepherd, Phoenix M.

AU - Yamamoto, Keisuke

AU - Razo, Elaina

AU - Krabbe, Nicholas P.

AU - Bliss, Mason I.

AU - Richardson, Alexander D.

AU - Einwalter, Morgan A.

AU - Weiler, Andrea M.

AU - Sneed, Emily L.

AU - Fuchs, Kerri B.

AU - Zeng, Xiankun

AU - Noguchi, Kevin K.

AU - Morgan, Terry K.

AU - Alberts, Alexandra J.

AU - Antony, Kathleen M.

AU - Kabakov, Sabrina

AU - Ausderau, Karla K.

AU - Bohm, Ellie K.

AU - Pritchard, Julia C.

AU - Spanton, Rachel V.

AU - Ver Hoove, James N.

AU - Kim, Charlene B.Y.

AU - Nork, T. Michael

AU - Katz, Alex W.

AU - Rasmussen, Carol A.

AU - Hartman, Amy

AU - Mejia, Andres

AU - Basu, Puja

AU - Simmons, Heather A.

AU - Eickhoff, Jens C.

AU - Friedrich, Thomas C.

AU - Aliota, Matthew T.

AU - Mohr, Emma L.

AU - Dudley, Dawn M.

AU - O’Connor, David H.

AU - Newman, Christina M.

N1 - Publisher Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

PY - 2023/3

Y1 - 2023/3

N2 - In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about the impacts of gestational African-lineage ZIKV infections. Given high human immunodeficiency virus (HIV) burdens in regions where African-lineage ZIKV circulates, we evaluated whether pregnant rhesus macaques infected with simian immunodeficiency virus (SIV) have a higher risk of African-lineage ZIKV-associated birth defects. Remarkably, in both SIV+ and SIV- animals, ZIKV infection early in the first trimester caused a high incidence (78%) of spontaneous pregnancy loss within 20 days. These findings suggest a significant risk for early pregnancy loss associated with African-lineage ZIKV infection and provide the first consistent ZIKV-associated phenotype in macaques for testing medical countermeasures.

AB - In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about the impacts of gestational African-lineage ZIKV infections. Given high human immunodeficiency virus (HIV) burdens in regions where African-lineage ZIKV circulates, we evaluated whether pregnant rhesus macaques infected with simian immunodeficiency virus (SIV) have a higher risk of African-lineage ZIKV-associated birth defects. Remarkably, in both SIV+ and SIV- animals, ZIKV infection early in the first trimester caused a high incidence (78%) of spontaneous pregnancy loss within 20 days. These findings suggest a significant risk for early pregnancy loss associated with African-lineage ZIKV infection and provide the first consistent ZIKV-associated phenotype in macaques for testing medical countermeasures.

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DO - 10.1371/journal.ppat.1011282

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C2 - 36976812

AN - SCOPUS:85152167398

SN - 1553-7366

VL - 19

JO - PLoS pathogens

JF - PLoS pathogens

IS - 3

M1 - e1011282

ER -

Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus

Abstract

Bibliographical note

UN SDGs

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