Abstract
A number of excitable cell types respond to a constant hormonal stimulus with a periodic oscillation in intracellular calcium. The frequency of oscillation is often proportional to the hormonal stimulus, and one says that the stimulus is frequency encoded. Here we develop a theory of frequency encoding in excitable systems and apply it to intracellular calcium oscillations that result from increases in the intracellular level of inositol 1,4,5-trisphosphate.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7869-7873 |
| Number of pages | 5 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 92 |
| Issue number | 17 |
| DOIs | |
| State | Published - Aug 15 1995 |
Keywords
- calcium channels
- inositol 1,4,5-trisphosphate
- mathematical model