Frequency encoding in excitable systems with applications to calcium oscillations

Yuanhua Tang, Hans G. Othmer

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


A number of excitable cell types respond to a constant hormonal stimulus with a periodic oscillation in intracellular calcium. The frequency of oscillation is often proportional to the hormonal stimulus, and one says that the stimulus is frequency encoded. Here we develop a theory of frequency encoding in excitable systems and apply it to intracellular calcium oscillations that result from increases in the intracellular level of inositol 1,4,5-trisphosphate.

Original languageEnglish (US)
Pages (from-to)7869-7873
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number17
StatePublished - Aug 15 1995


  • calcium channels
  • inositol 1,4,5-trisphosphate
  • mathematical model


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