Free thyroxine levels in critically ill patients. A comparison of currently available assays

M. F. Slag, J. E. Morley, M. K. Elson, K. R. Labrosse, T. W. Crowson, frank q Nuttall, R. B. Shafer

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Two indices of free thyroxin (T4) and four methods of free T4 measurement were compared in 85 patients with acute illness, hospitalized in intensive care units. All of the methods of free T4 measurement in critical illness were nonspecific, and two of the methods failed to suggest hypothyroidism in two patients with primary hypothyroidism and another associated critical illness. Since the ideal screening test should be both sensitive and specific, all tests for free T4 used in this study should be interpreted with caution in severely ill patients.

Original languageEnglish (US)
Pages (from-to)2702-2706
Number of pages5
JournalJournal of the American Medical Association
Volume246
Issue number23
DOIs
StatePublished - Dec 1 1981
Externally publishedYes

Fingerprint

Thyroxine
Critical Illness
Hypothyroidism
Intensive Care Units

Cite this

Slag, M. F., Morley, J. E., Elson, M. K., Labrosse, K. R., Crowson, T. W., Nuttall, F. Q., & Shafer, R. B. (1981). Free thyroxine levels in critically ill patients. A comparison of currently available assays. Journal of the American Medical Association, 246(23), 2702-2706. https://doi.org/10.1001/jama.246.23.2702

Free thyroxine levels in critically ill patients. A comparison of currently available assays. / Slag, M. F.; Morley, J. E.; Elson, M. K.; Labrosse, K. R.; Crowson, T. W.; Nuttall, frank q; Shafer, R. B.

In: Journal of the American Medical Association, Vol. 246, No. 23, 01.12.1981, p. 2702-2706.

Research output: Contribution to journalArticle

Slag, MF, Morley, JE, Elson, MK, Labrosse, KR, Crowson, TW, Nuttall, FQ & Shafer, RB 1981, 'Free thyroxine levels in critically ill patients. A comparison of currently available assays', Journal of the American Medical Association, vol. 246, no. 23, pp. 2702-2706. https://doi.org/10.1001/jama.246.23.2702
Slag, M. F. ; Morley, J. E. ; Elson, M. K. ; Labrosse, K. R. ; Crowson, T. W. ; Nuttall, frank q ; Shafer, R. B. / Free thyroxine levels in critically ill patients. A comparison of currently available assays. In: Journal of the American Medical Association. 1981 ; Vol. 246, No. 23. pp. 2702-2706.
@article{8e8aebfb4eb14adcbcd209236bd3ec27,
title = "Free thyroxine levels in critically ill patients. A comparison of currently available assays",
abstract = "Two indices of free thyroxin (T4) and four methods of free T4 measurement were compared in 85 patients with acute illness, hospitalized in intensive care units. All of the methods of free T4 measurement in critical illness were nonspecific, and two of the methods failed to suggest hypothyroidism in two patients with primary hypothyroidism and another associated critical illness. Since the ideal screening test should be both sensitive and specific, all tests for free T4 used in this study should be interpreted with caution in severely ill patients.",
author = "Slag, {M. F.} and Morley, {J. E.} and Elson, {M. K.} and Labrosse, {K. R.} and Crowson, {T. W.} and Nuttall, {frank q} and Shafer, {R. B.}",
year = "1981",
month = "12",
day = "1",
doi = "10.1001/jama.246.23.2702",
language = "English (US)",
volume = "246",
pages = "2702--2706",
journal = "JAMA - Journal of the American Medical Association",
issn = "0098-7484",
publisher = "American Medical Association",
number = "23",

}

TY - JOUR

T1 - Free thyroxine levels in critically ill patients. A comparison of currently available assays

AU - Slag, M. F.

AU - Morley, J. E.

AU - Elson, M. K.

AU - Labrosse, K. R.

AU - Crowson, T. W.

AU - Nuttall, frank q

AU - Shafer, R. B.

PY - 1981/12/1

Y1 - 1981/12/1

N2 - Two indices of free thyroxin (T4) and four methods of free T4 measurement were compared in 85 patients with acute illness, hospitalized in intensive care units. All of the methods of free T4 measurement in critical illness were nonspecific, and two of the methods failed to suggest hypothyroidism in two patients with primary hypothyroidism and another associated critical illness. Since the ideal screening test should be both sensitive and specific, all tests for free T4 used in this study should be interpreted with caution in severely ill patients.

AB - Two indices of free thyroxin (T4) and four methods of free T4 measurement were compared in 85 patients with acute illness, hospitalized in intensive care units. All of the methods of free T4 measurement in critical illness were nonspecific, and two of the methods failed to suggest hypothyroidism in two patients with primary hypothyroidism and another associated critical illness. Since the ideal screening test should be both sensitive and specific, all tests for free T4 used in this study should be interpreted with caution in severely ill patients.

UR - http://www.scopus.com/inward/record.url?scp=0019823058&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019823058&partnerID=8YFLogxK

U2 - 10.1001/jama.246.23.2702

DO - 10.1001/jama.246.23.2702

M3 - Article

C2 - 6796703

VL - 246

SP - 2702

EP - 2706

JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

SN - 0098-7484

IS - 23

ER -