Free Thyroxine Index and risk of stroke: Results from the National Health and Nutrition Examination Survey follow-up study

Adnan I. Qureshi, M. Fareed K Suri, Abu Nasar, Jawad F. Kirmani, Afshin A. Divani, Wayne H. Giles

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Background: The long-term risks of stroke associated with hypothyroidism and hyperthyroidism is unknown. We evaluated the long-term risk of stroke with hypothyroidism and hyperthyroidism compared with euthyroid status. Material/Methods: We used the 20-year follow-up data for adults aged 25 to 74 years who participated in the First National Health and Nutrition Examination Survey Follow-up Study. Hypothyroidism or hyperthyroidism was diagnosed by free thyroxine index measurements at baseline evaluation and incident events were determined from hospital records and death certificates during follow-up. Relative risk (RR) of stroke, ischemic stroke, and intracerebral hemorrhage for each category of thyroid function were determined by Cox proportional hazards analysis after adjustment for potential confounding variables. Results: A total of 5,269 participants (mean age 48±14 years; 2,379 men) were evaluated. Hypothyroidism and hyperthyroidism were diagnosed in 493 (9.4%) and 34 (0.7%) participants, respectively. After adjustment for covariates, a significantly higher RR for all strokes and for ischemic stroke was observed in participants with hypothyroidism (RR 1.6; 95% confidence interval (CI), 1.0-2.6 and RR 1.6, 95% CI, 1.0-2.7, respectively). Hyperthyroidism was not associated with an increased risk for stroke. Conclusions: An increased risk for stroke (particularly ischemic stroke) was observed in patients with hypothyroidism.

Original languageEnglish (US)
Pages (from-to)CR501-CR506
JournalMedical Science Monitor
Volume12
Issue number12
StatePublished - Dec 1 2006

Keywords

  • Hyperthyroidism
  • Hypothyroidism
  • Intracerebral hemorrhage
  • National survey
  • Stroke

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