Free radical-mediated postischemic injury in renal transplantation

Mark S Paller

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Oxygen free radicals are generated during reperfusion of ischemic organs. Studies employing several species of laboratory animal (rat, dog, pig, rabbit, mouse) have documented protective effects of a variety of free-radical scavengers and antioxidants when administered before or immediately preceding reperfusion of ischemic kidneys. These protective agents include superoxide dismutase, dimethylthiorea, dimethyl sulfoxide, αtocopherol, glutathione, the iron chelator deferoxamine, probucol, allopurinol and oxypurinol, and the spin-trapping agent PBN. Furthermore, deficiency of antioxidants (selenium, αtocopherol, orcatalase) exacerbates postischemic renal injury. These findings have been applied to renal transplantation in an attempt to decrease the incidence of posttransplantation acute renal failure. This is important because acute renal failure results in morbidity, increases hospital stay and the cost of transplantation, and complicates the use of cyclosporine. In porcine and in canine kidney transplantation, superoxide dismutase and allopurinol have provided renal protection. Transplantation is complicated because there may be prolonged hypoperfusion before harvesting plus a brief period of total ischemia during harvesting, followed by a prolonged period of cold ischemia and/or reperfusion, then followed by another brief period of ischemia and reperfusion during transplantation. Injury may occur at each of these phases by different mechanisms.

Original languageEnglish (US)
Pages (from-to)257-260
Number of pages4
JournalRenal Failure
Volume14
Issue number3
DOIs
StatePublished - Jan 1 1992

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Kidney Transplantation
Reperfusion
Free Radicals
Allopurinol
Tocopherols
Transplantation
Wounds and Injuries
Kidney
Acute Kidney Injury
Superoxide Dismutase
Swine
Ischemia
Oxypurinol
Antioxidants
Probucol
Spin Trapping
Cold Ischemia
Protective Agents
Free Radical Scavengers
Deferoxamine

Cite this

Free radical-mediated postischemic injury in renal transplantation. / Paller, Mark S.

In: Renal Failure, Vol. 14, No. 3, 01.01.1992, p. 257-260.

Research output: Contribution to journalArticle

Paller, Mark S. / Free radical-mediated postischemic injury in renal transplantation. In: Renal Failure. 1992 ; Vol. 14, No. 3. pp. 257-260.
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