Free-breathing post-contrast three-dimensional T1 mapping: Volumetric assessment of myocardial T1 values

Sebastian Weingärtner, Mehmet Akçakaya, Sébastien Roujol, Tamer Basha, Christian Stehning, Kraig V. Kissinger, Beth Goddu, Sophie Berg, Warren J. Manning, Reza Nezafat

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Purpose: To develop a three-dimensional (3D) free-breathing myocardial T1 mapping sequence for assessment of left ventricle diffuse fibrosis after contrast administration.

Methods: In the proposed sequence, multiple 3D inversion recovery images are acquired in an interleaved manner. A mixed prospective/retrospective navigator scheme is used to obtain the 3D Cartesian k-space data with fully sampled center and randomly undersampled outer k-space. The resulting undersampled 3D k-space data are then reconstructed using compressed sensing. Subsequently, T1 maps are generated by voxel-wise curve fitting of the individual interleaved images. In a phantom study, the accuracy of the 3D sequence was evaluated against two-dimensional (2D) modified Look-Locker inversion recovery (MOLLI) and spin-echo sequences. In vivo T1 times of the proposed method were compared with 2D multislice MOLLI T1 mapping. Subsequently, the feasibility of high-resolution 3D T1 mapping with spatial resolution of 1.7 × 1.7 × 4 mm3 was demonstrated.

Results: The proposed method shows good agreement with 2D MOLLI and the spin-echo reference in phantom. No significant difference was found in the in vivo T1 times estimated using the proposed sequence and the 2D MOLLI technique (myocardium, 330±66ms versus 319±93 ms; blood pools, 211±68 ms versus 210±98 ms). However, improved homogeneity, as measured using standard deviation of the T1 signal, was observed in the 3D T1 maps.

Conclusion: The proposed sequence enables high-resolution 3D T1 mapping after contrast injection during free-breathing with volumetric left ventricle coverage.

Original languageEnglish (US)
Pages (from-to)214-222
Number of pages9
JournalMagnetic resonance in medicine
Issue number1
StatePublished - Jan 1 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014 Wiley Periodicals, Inc.


  • Diffused fibrosis
  • Myocardial T mapping
  • Navigator gating
  • Quantitative cardiac mri


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