Free and Protein-Bound Lysine Flux in Developing Rabbit Brain

Kenneth F. Swaiman, Richard N. Wolfe

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The rate of flux of lysine from plasma to the nonprotein nitrogen fraction of brain and the rate of flux of lysine from the nonprotein nitrogen fraction to brain proteins is greater in newborn rabbits than in rabbits 12 days old. These in vivo findings parallel the in vitro findings of other investigators that cerebral tissue in the newborn has greater ability to incorporate amino acids into brain protein than cerebral tissue removed from slightly older animals. The greater rate of flux of lysine into protein of the more immature brain most likely is a reflection of the dominance of the synthesis of rapidly metabolized brain proteins at this age.

Original languageEnglish (US)
Pages (from-to)411-414
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume127
Issue number2
DOIs
StatePublished - Feb 1968

Bibliographical note

Funding Information:
Supported in part by USPHS grant No. NB-05015 and a grant from the Havel Fund.

Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.

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