This work presents a comprehensive framework for research in Management Information Systems (MIS). The necessity for a more comprehensive research framework is derived from a review of past research frameworks. The new framework is validated by mapping 331 MIS doctoral dissertations into its research categories. The dissertations are also classified by research methodology employed. The comprehensive MIS research model is useful not only in understanding and classifying MIS research but also in generating potential hypotheses for future research. Hypothesis generation using the model is explained and illustrated.