Frailty and multiple comorbidities in the elderly patient with heart failure: Implications for management

Khalil Murad, Dalane W. Kitzman

Research output: Contribution to journalReview article

88 Scopus citations

Abstract

Heart failure (HF) in the elderly is a major public health problem, and its prevalence is rising. Outcomes of HF in the elderly have not changed in the past 2 decades despite the introduction of novel HF therapies. This may be due to the combined impact of multiple comorbidities and frailty. The majority of elderly patients with HF are frail with multiple comorbidities. These comorbidities, along with frailty, contribute to the poor outcome of HF in the elderly and pose independent management challenges. More research is needed to better understand the interaction between frailty and multiple comorbidities and the mechanisms by which they impact HF and its management; develop prognostic tools that incorporate frailty and multiple comorbidities and provide more accurate prediction of outcomes; test available treatments in typical elderly patients; and develop and test novel interventions that directly address the adverse impact of multiple comorbidities and frailty.

Original languageEnglish (US)
Pages (from-to)581-588
Number of pages8
JournalHeart Failure Reviews
Volume17
Issue number4-5
DOIs
StatePublished - Sep 1 2012

Keywords

  • Aging
  • Chronic diseases
  • Outcomes
  • Rehospitalization

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