Frailty and hip osteoarthritis in men in the MrOS cohort

Barton L. Wise, Neeta Parimi, Yuqing Zhang, Peggy M. Cawthon, Elizabeth Barrett-Connor, Kristine E. Ensrud, Nancy E. Lane

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Background.Frailty has been associated in previous studies with increased mortality and morbidity, but little has been published on its association with arthritis. This study examined the association of hip osteoarthritis to frailty status in a longitudinal observational cohort of older men in the Osteoporotic Fractures in Men Study.Methods.Participants (N = 4,130) were men aged 65 years and older with complete frailty status and hip radiographs. We defined frailty as three or more of the following components: unintentional weight loss, weakness, self-reported exhaustion, low activity level, and slow walking speed. Men with intermediate stage status met one or two criteria while robust men had none. We defined radiographic hip osteoarthritis (RHOA) as a modified Croft score greater than or equal to 2 on hip radiograph. The relation of RHOA or total hip replacement (THR) to frailty status was examined in cross-sectional and incident analyses using logistic regression.Results.Prevalence of robust, intermediate, and frail status was 50%, 42%, and 8%, respectively. RHOA or THR was associated with increased odds of being frail or intermediate compared with robust (adjusted odds ratio = 1.45, 95% confidence interval [CI] 1.18, 1.78). Men with RHOA or THR were 1.27 times more likely to have incident frail or intermediate status compared with robust (95% CI: 1.19, 1.38).Conclusions.RHOA and THR are associated with greater frailty status in older men, suggesting that interventions to reduce frailty should be evaluated in older men with either RHOA or THR.

Original languageEnglish (US)
Pages (from-to)602-608
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume69 A
Issue number5
StatePublished - May 2014

Bibliographical note

Funding Information:
Funding This work was supported by the following funding sources: the University of California, Davis Building Interdisciplinary Research Careers in Women’s Health Program (NIH K12 HD051958 and NIH P50 AR063043 to B.L.W.; NIH K24 AR048841 to N.E.L.; and NIH P50 AR060752) and the Endowed Chair for Aging at University of California, Davis School of Medicine to N.E.L. The MrOS study is supported by National Institutes of Health. The following institutes provided support: the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); the National Institute on Aging (NIA); the National Center for Research Resources (NCRR); and NIH Roadmap for Medical Research (U01 AR45580, U01 AR45614, U01 AR45632, U01 AR45647, U01 AR45654, U01 AR45583, U01 AG18197, U01 AG027810, and UL1 RR024140). The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) provided funding for the MrOS Hip OA ancillary study “Epidemiology and Genetics of Hip OA in Elderly Men” (R01 AR052000).


  • Frailty
  • Hip
  • Older men.
  • Osteoarthritis


Dive into the research topics of 'Frailty and hip osteoarthritis in men in the MrOS cohort'. Together they form a unique fingerprint.

Cite this