Fragmentation Haemolysis in Patients with Severe Diabetic Angiopathy

R. D. Brunning, H. S. Jacob, W. D. Brenckman, F. Jimenez‐pasquau, F. C. Goetz

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Haemolytic anaemia associated with prominent red cell fragmentation is described in seven patients with long‐standing diabetes mellitus. A common feature in the patients was severe microangiopathy as detected by retinal examination and microscopic examination of the kidneys. Renal or pancreatic islet malfunction per se is not involved in the haemolytic syndrome, since red cell abnormalities persisted in one patient for over a year following successful renal and pancreatic transplantation—this, despite the maintenance of normal renal and carbohydrate homeostasis. The kinetics of fragmentation was studied by transfusing normal type O cells into this type A patient. With reisolation of these cells by the Ashby‐technique, rapid and progressive red cell fragmentation was demonstrated by: (a) membrane lipid loss; (b) osmotic fragility increase; and (c) increase in mean cell haemoglobin concentration. These studies indicate that a red‐cell‐fragmentation haemolytic anaemia may occur in long‐standing diabetes mellitus, related to the angiopathy of this disease and not to insulin deficiency or renal malfunction.

Original languageEnglish (US)
Pages (from-to)283-289
Number of pages7
JournalBritish Journal of Haematology
Volume34
Issue number2
DOIs
StatePublished - Jan 1 1976

Fingerprint

Diabetic Angiopathies
Hemolysis
Kidney
Hemolytic Anemia
Diabetes Mellitus
Osmotic Fragility
Erythrocyte Indices
Membrane Lipids
Islets of Langerhans
Homeostasis
Maintenance
Carbohydrates
Insulin

Cite this

Fragmentation Haemolysis in Patients with Severe Diabetic Angiopathy. / Brunning, R. D.; Jacob, H. S.; Brenckman, W. D.; Jimenez‐pasquau, F.; Goetz, F. C.

In: British Journal of Haematology, Vol. 34, No. 2, 01.01.1976, p. 283-289.

Research output: Contribution to journalArticle

Brunning, R. D. ; Jacob, H. S. ; Brenckman, W. D. ; Jimenez‐pasquau, F. ; Goetz, F. C. / Fragmentation Haemolysis in Patients with Severe Diabetic Angiopathy. In: British Journal of Haematology. 1976 ; Vol. 34, No. 2. pp. 283-289.
@article{21ebe6f4f4f2491b8c825a3adf9d049c,
title = "Fragmentation Haemolysis in Patients with Severe Diabetic Angiopathy",
abstract = "Haemolytic anaemia associated with prominent red cell fragmentation is described in seven patients with long‐standing diabetes mellitus. A common feature in the patients was severe microangiopathy as detected by retinal examination and microscopic examination of the kidneys. Renal or pancreatic islet malfunction per se is not involved in the haemolytic syndrome, since red cell abnormalities persisted in one patient for over a year following successful renal and pancreatic transplantation—this, despite the maintenance of normal renal and carbohydrate homeostasis. The kinetics of fragmentation was studied by transfusing normal type O cells into this type A patient. With reisolation of these cells by the Ashby‐technique, rapid and progressive red cell fragmentation was demonstrated by: (a) membrane lipid loss; (b) osmotic fragility increase; and (c) increase in mean cell haemoglobin concentration. These studies indicate that a red‐cell‐fragmentation haemolytic anaemia may occur in long‐standing diabetes mellitus, related to the angiopathy of this disease and not to insulin deficiency or renal malfunction.",
author = "Brunning, {R. D.} and Jacob, {H. S.} and Brenckman, {W. D.} and F. Jimenez‐pasquau and Goetz, {F. C.}",
year = "1976",
month = "1",
day = "1",
doi = "10.1111/j.1365-2141.1976.tb00198.x",
language = "English (US)",
volume = "34",
pages = "283--289",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Fragmentation Haemolysis in Patients with Severe Diabetic Angiopathy

AU - Brunning, R. D.

AU - Jacob, H. S.

AU - Brenckman, W. D.

AU - Jimenez‐pasquau, F.

AU - Goetz, F. C.

PY - 1976/1/1

Y1 - 1976/1/1

N2 - Haemolytic anaemia associated with prominent red cell fragmentation is described in seven patients with long‐standing diabetes mellitus. A common feature in the patients was severe microangiopathy as detected by retinal examination and microscopic examination of the kidneys. Renal or pancreatic islet malfunction per se is not involved in the haemolytic syndrome, since red cell abnormalities persisted in one patient for over a year following successful renal and pancreatic transplantation—this, despite the maintenance of normal renal and carbohydrate homeostasis. The kinetics of fragmentation was studied by transfusing normal type O cells into this type A patient. With reisolation of these cells by the Ashby‐technique, rapid and progressive red cell fragmentation was demonstrated by: (a) membrane lipid loss; (b) osmotic fragility increase; and (c) increase in mean cell haemoglobin concentration. These studies indicate that a red‐cell‐fragmentation haemolytic anaemia may occur in long‐standing diabetes mellitus, related to the angiopathy of this disease and not to insulin deficiency or renal malfunction.

AB - Haemolytic anaemia associated with prominent red cell fragmentation is described in seven patients with long‐standing diabetes mellitus. A common feature in the patients was severe microangiopathy as detected by retinal examination and microscopic examination of the kidneys. Renal or pancreatic islet malfunction per se is not involved in the haemolytic syndrome, since red cell abnormalities persisted in one patient for over a year following successful renal and pancreatic transplantation—this, despite the maintenance of normal renal and carbohydrate homeostasis. The kinetics of fragmentation was studied by transfusing normal type O cells into this type A patient. With reisolation of these cells by the Ashby‐technique, rapid and progressive red cell fragmentation was demonstrated by: (a) membrane lipid loss; (b) osmotic fragility increase; and (c) increase in mean cell haemoglobin concentration. These studies indicate that a red‐cell‐fragmentation haemolytic anaemia may occur in long‐standing diabetes mellitus, related to the angiopathy of this disease and not to insulin deficiency or renal malfunction.

UR - http://www.scopus.com/inward/record.url?scp=0017109737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017109737&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2141.1976.tb00198.x

DO - 10.1111/j.1365-2141.1976.tb00198.x

M3 - Article

C2 - 974041

AN - SCOPUS:0017109737

VL - 34

SP - 283

EP - 289

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 2

ER -