Fragile X Tremor/Ataxia Syndrome: Blame the Messenger!

Maurice S. Swanson; Harry T. Orr

doi:10.1016/j.neuron.2007.07.032

Fragile X Tremor/Ataxia Syndrome: Blame the Messenger!

Maurice S. Swanson
, Harry T. Orr

Research output: Contribution to journal › Short survey › peer-review

15 Scopus citations

Abstract

rCGG repeats in premutant alleles of the fragile X gene (FMR1) cause neurodegeneration in Drosophila and are thought to cause fragile X-associated tremor/ataxia syndrome in humans. Two reports in this issue of Neuron (Jin et al. and Sofola et al.) present data indicating a disease mechanism involving disruption of RNA-binding protein function.

Original language	English (US)
Pages (from-to)	535-537
Number of pages	3
Journal	Neuron
Volume	55
Issue number	4
DOIs	https://doi.org/10.1016/j.neuron.2007.07.032
State	Published - Aug 16 2007

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10.1016/j.neuron.2007.07.032

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title = "Fragile X Tremor/Ataxia Syndrome: Blame the Messenger!",

abstract = "rCGG repeats in premutant alleles of the fragile X gene (FMR1) cause neurodegeneration in Drosophila and are thought to cause fragile X-associated tremor/ataxia syndrome in humans. Two reports in this issue of Neuron (Jin et al. and Sofola et al.) present data indicating a disease mechanism involving disruption of RNA-binding protein function.",

author = "Swanson, \{Maurice S.\} and Orr, \{Harry T.\}",

year = "2007",

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language = "English (US)",

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pages = "535--537",

journal = "Neuron",

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TY - JOUR

T1 - Fragile X Tremor/Ataxia Syndrome

T2 - Blame the Messenger!

AU - Swanson, Maurice S.

AU - Orr, Harry T.

PY - 2007/8/16

Y1 - 2007/8/16

N2 - rCGG repeats in premutant alleles of the fragile X gene (FMR1) cause neurodegeneration in Drosophila and are thought to cause fragile X-associated tremor/ataxia syndrome in humans. Two reports in this issue of Neuron (Jin et al. and Sofola et al.) present data indicating a disease mechanism involving disruption of RNA-binding protein function.

AB - rCGG repeats in premutant alleles of the fragile X gene (FMR1) cause neurodegeneration in Drosophila and are thought to cause fragile X-associated tremor/ataxia syndrome in humans. Two reports in this issue of Neuron (Jin et al. and Sofola et al.) present data indicating a disease mechanism involving disruption of RNA-binding protein function.

UR - https://www.scopus.com/pages/publications/34547650713

UR - https://www.scopus.com/pages/publications/34547650713#tab=citedBy

U2 - 10.1016/j.neuron.2007.07.032

DO - 10.1016/j.neuron.2007.07.032

M3 - Short survey

C2 - 17698005

AN - SCOPUS:34547650713

SN - 0896-6273

VL - 55

SP - 535

EP - 537

JO - Neuron

JF - Neuron

IS - 4

ER -

Fragile X Tremor/Ataxia Syndrome: Blame the Messenger!

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