TY - GEN
T1 - Fractal dimension detects seizure onset in mesial temporal lobe epilepsy
AU - Esteller, R.
AU - Vachtsevanos, G.
AU - Echauz, J.
AU - D'Alessandro, M.
AU - Bowen, C.
AU - Shor, R.
AU - Litt, B.
PY - 1999
Y1 - 1999
N2 - The fractal dimension (FD) of a waveform is presented as a tool for detecting electrographic and predicting clinical onset of seizures (Sz) in 5 patients with mesial temporal lobe epilepsy (MTLE). Sixty-seven 1-hour intracranial EEG (IEEG) records, 25 containing Szs and 42 randomly chosen baselines ≥6 hrs from Szs, were analyzed from 5 patients during pre-surgical evaluation. Szs were detected an average of 9.8 seconds after EEG onset and 52 seconds prior to clinical onset. There were no false positive or false negative detections. We conclude that FD of the IEEG waveform is a promising method for real-time detection of electrographic and prediction of clinical onset of epileptic Szs early enough to warn of impending events and potentially to trigger abortive therapy.
AB - The fractal dimension (FD) of a waveform is presented as a tool for detecting electrographic and predicting clinical onset of seizures (Sz) in 5 patients with mesial temporal lobe epilepsy (MTLE). Sixty-seven 1-hour intracranial EEG (IEEG) records, 25 containing Szs and 42 randomly chosen baselines ≥6 hrs from Szs, were analyzed from 5 patients during pre-surgical evaluation. Szs were detected an average of 9.8 seconds after EEG onset and 52 seconds prior to clinical onset. There were no false positive or false negative detections. We conclude that FD of the IEEG waveform is a promising method for real-time detection of electrographic and prediction of clinical onset of epileptic Szs early enough to warn of impending events and potentially to trigger abortive therapy.
UR - https://www.scopus.com/pages/publications/0033313669
UR - https://www.scopus.com/pages/publications/0033313669#tab=citedBy
M3 - Conference contribution
AN - SCOPUS:0033313669
SN - 0780356756
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 442
BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PB - IEEE
T2 - Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
Y2 - 13 October 1999 through 16 October 1999
ER -