Four new recurring translocations in non-Hodgkin lymphoma

E. G. Levine; D. C. Arthur; J. Machnicki; G. Frizzera; D. Hurd; B. Peterson; K. J. Gaji-Peczalska; C. D. Bloomfield

doi:10.1182/blood.v74.5.1796.1796

Four new recurring translocations in non-Hodgkin lymphoma

E. G. Levine, D. C. Arthur, J. Machnicki, G. Frizzera, D. Hurd, B. Peterson, K. J. Gaji-Peczalska, C. D. Bloomfield

Medicine - Hematology, Oncology, Transplant

Research output: Contribution to journal › Article

86 Scopus citations

Abstract

The identification of recurring chromosomal translocations has provided clues to the gene regions important in lymphoma development. Among 157 patients with non-Hodgkin lymphoma studied by cytogenetic analysis, four new recurring translocations have been identified - t(8;9)(q24;p13), t(11;18)(q21;q21), t(14,15)(q32;q15), and an unbalanced translocation giving rise to der(22)t(17;22)(q11;p11). Each translocation appeared twice. The t(11;18) was the only karyotypic abnormality in the two patients with it, and the t(14;15) was the sole karyotypic abnormality in one patient. All translocations were found in B-cell malignancies and were associated with both nodal and extranodal disease. Among the regions affected, only the immunoglobulin heavy-chain gene MYC, and BCL2, have thus far been associated with lymphoma. The breakpoint sites identified by these translocations warrant further investigation at the molecular level.

Original language	English (US)
Pages (from-to)	1796-1800
Number of pages	5
Journal	Blood
Volume	74
Issue number	5
DOIs	https://doi.org/10.1182/blood.v74.5.1796.1796
State	Published - 1989

Access

10.1182/blood.v74.5.1796.1796

Fingerprint Dive into the research topics of 'Four new recurring translocations in non-Hodgkin lymphoma'. Together they form a unique fingerprint.

Cite this

Levine, E. G., Arthur, D. C., Machnicki, J., Frizzera, G., Hurd, D., Peterson, B., Gaji-Peczalska, K. J., & Bloomfield, C. D. (1989). Four new recurring translocations in non-Hodgkin lymphoma. Blood, 74(5), 1796-1800. https://doi.org/10.1182/blood.v74.5.1796.1796

@article{933b64b93a604418934b6a2e3ecde044,

title = "Four new recurring translocations in non-Hodgkin lymphoma",

abstract = "The identification of recurring chromosomal translocations has provided clues to the gene regions important in lymphoma development. Among 157 patients with non-Hodgkin lymphoma studied by cytogenetic analysis, four new recurring translocations have been identified - t(8;9)(q24;p13), t(11;18)(q21;q21), t(14,15)(q32;q15), and an unbalanced translocation giving rise to der(22)t(17;22)(q11;p11). Each translocation appeared twice. The t(11;18) was the only karyotypic abnormality in the two patients with it, and the t(14;15) was the sole karyotypic abnormality in one patient. All translocations were found in B-cell malignancies and were associated with both nodal and extranodal disease. Among the regions affected, only the immunoglobulin heavy-chain gene MYC, and BCL2, have thus far been associated with lymphoma. The breakpoint sites identified by these translocations warrant further investigation at the molecular level.",

author = "Levine, {E. G.} and Arthur, {D. C.} and J. Machnicki and G. Frizzera and D. Hurd and B. Peterson and Gaji-Peczalska, {K. J.} and Bloomfield, {C. D.}",

year = "1989",

doi = "10.1182/blood.v74.5.1796.1796",

language = "English (US)",

volume = "74",

pages = "1796--1800",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

number = "5",

}

TY - JOUR

T1 - Four new recurring translocations in non-Hodgkin lymphoma

AU - Levine, E. G.

AU - Arthur, D. C.

AU - Machnicki, J.

AU - Frizzera, G.

AU - Hurd, D.

AU - Peterson, B.

AU - Gaji-Peczalska, K. J.

AU - Bloomfield, C. D.

PY - 1989

Y1 - 1989

N2 - The identification of recurring chromosomal translocations has provided clues to the gene regions important in lymphoma development. Among 157 patients with non-Hodgkin lymphoma studied by cytogenetic analysis, four new recurring translocations have been identified - t(8;9)(q24;p13), t(11;18)(q21;q21), t(14,15)(q32;q15), and an unbalanced translocation giving rise to der(22)t(17;22)(q11;p11). Each translocation appeared twice. The t(11;18) was the only karyotypic abnormality in the two patients with it, and the t(14;15) was the sole karyotypic abnormality in one patient. All translocations were found in B-cell malignancies and were associated with both nodal and extranodal disease. Among the regions affected, only the immunoglobulin heavy-chain gene MYC, and BCL2, have thus far been associated with lymphoma. The breakpoint sites identified by these translocations warrant further investigation at the molecular level.

AB - The identification of recurring chromosomal translocations has provided clues to the gene regions important in lymphoma development. Among 157 patients with non-Hodgkin lymphoma studied by cytogenetic analysis, four new recurring translocations have been identified - t(8;9)(q24;p13), t(11;18)(q21;q21), t(14,15)(q32;q15), and an unbalanced translocation giving rise to der(22)t(17;22)(q11;p11). Each translocation appeared twice. The t(11;18) was the only karyotypic abnormality in the two patients with it, and the t(14;15) was the sole karyotypic abnormality in one patient. All translocations were found in B-cell malignancies and were associated with both nodal and extranodal disease. Among the regions affected, only the immunoglobulin heavy-chain gene MYC, and BCL2, have thus far been associated with lymphoma. The breakpoint sites identified by these translocations warrant further investigation at the molecular level.

UR - http://www.scopus.com/inward/record.url?scp=0024468639&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024468639&partnerID=8YFLogxK

U2 - 10.1182/blood.v74.5.1796.1796

DO - 10.1182/blood.v74.5.1796.1796

M3 - Article

C2 - 2506953

AN - SCOPUS:0024468639

VL - 74

SP - 1796

EP - 1800

JO - Blood

JF - Blood

SN - 0006-4971

IS - 5

ER -