TY - JOUR
T1 - Four new recurring translocations in non-Hodgkin lymphoma
AU - Levine, E. G.
AU - Arthur, D. C.
AU - Machnicki, J.
AU - Frizzera, G.
AU - Hurd, D.
AU - Peterson, B.
AU - Gaji-Peczalska, K. J.
AU - Bloomfield, C. D.
PY - 1989
Y1 - 1989
N2 - The identification of recurring chromosomal translocations has provided clues to the gene regions important in lymphoma development. Among 157 patients with non-Hodgkin lymphoma studied by cytogenetic analysis, four new recurring translocations have been identified - t(8;9)(q24;p13), t(11;18)(q21;q21), t(14,15)(q32;q15), and an unbalanced translocation giving rise to der(22)t(17;22)(q11;p11). Each translocation appeared twice. The t(11;18) was the only karyotypic abnormality in the two patients with it, and the t(14;15) was the sole karyotypic abnormality in one patient. All translocations were found in B-cell malignancies and were associated with both nodal and extranodal disease. Among the regions affected, only the immunoglobulin heavy-chain gene MYC, and BCL2, have thus far been associated with lymphoma. The breakpoint sites identified by these translocations warrant further investigation at the molecular level.
AB - The identification of recurring chromosomal translocations has provided clues to the gene regions important in lymphoma development. Among 157 patients with non-Hodgkin lymphoma studied by cytogenetic analysis, four new recurring translocations have been identified - t(8;9)(q24;p13), t(11;18)(q21;q21), t(14,15)(q32;q15), and an unbalanced translocation giving rise to der(22)t(17;22)(q11;p11). Each translocation appeared twice. The t(11;18) was the only karyotypic abnormality in the two patients with it, and the t(14;15) was the sole karyotypic abnormality in one patient. All translocations were found in B-cell malignancies and were associated with both nodal and extranodal disease. Among the regions affected, only the immunoglobulin heavy-chain gene MYC, and BCL2, have thus far been associated with lymphoma. The breakpoint sites identified by these translocations warrant further investigation at the molecular level.
UR - http://www.scopus.com/inward/record.url?scp=0024468639&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024468639&partnerID=8YFLogxK
U2 - 10.1182/blood.v74.5.1796.1796
DO - 10.1182/blood.v74.5.1796.1796
M3 - Article
C2 - 2506953
AN - SCOPUS:0024468639
SN - 0006-4971
VL - 74
SP - 1796
EP - 1800
JO - Blood
JF - Blood
IS - 5
ER -