Four new recurring translocations in non-Hodgkin lymphoma

E. G. Levine, D. C. Arthur, J. Machnicki, G. Frizzera, D. Hurd, B. Peterson, K. J. Gaji-Peczalska, C. D. Bloomfield

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Abstract

The identification of recurring chromosomal translocations has provided clues to the gene regions important in lymphoma development. Among 157 patients with non-Hodgkin lymphoma studied by cytogenetic analysis, four new recurring translocations have been identified - t(8;9)(q24;p13), t(11;18)(q21;q21), t(14,15)(q32;q15), and an unbalanced translocation giving rise to der(22)t(17;22)(q11;p11). Each translocation appeared twice. The t(11;18) was the only karyotypic abnormality in the two patients with it, and the t(14;15) was the sole karyotypic abnormality in one patient. All translocations were found in B-cell malignancies and were associated with both nodal and extranodal disease. Among the regions affected, only the immunoglobulin heavy-chain gene MYC, and BCL2, have thus far been associated with lymphoma. The breakpoint sites identified by these translocations warrant further investigation at the molecular level.

Original languageEnglish (US)
Pages (from-to)1796-1800
Number of pages5
JournalBlood
Volume74
Issue number5
DOIs
StatePublished - 1989

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    Levine, E. G., Arthur, D. C., Machnicki, J., Frizzera, G., Hurd, D., Peterson, B., Gaji-Peczalska, K. J., & Bloomfield, C. D. (1989). Four new recurring translocations in non-Hodgkin lymphoma. Blood, 74(5), 1796-1800. https://doi.org/10.1182/blood.v74.5.1796.1796