Foscarnet for suppression of human immunodeficiency virus replication

C. V. Fletcher, A. C. Collier, F. S. Rhame, D. Bennett, M. F. Para, C. C. Beatty, C. E. Jones, H. H. Balfour

Research output: Contribution to journalComment/debate

31 Scopus citations

Abstract

The effect of foscarnet against human immunodeficiency virus (HIV) was evaluated in nine HIV-infected individuals; six completed 28 days of induction therapy. The overall mean increase in CD4+ lymphocytes was 64 cells per mm3. The mean decline in the HIV antigen concentration was 108 pg/ml (P = 0.03), and suppression was related to systemic foscarnet exposure by a maximum-effect pharmacodynamic model.

Original languageEnglish (US)
Pages (from-to)604-607
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume38
Issue number3
DOIs
StatePublished - 1994

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    Fletcher, C. V., Collier, A. C., Rhame, F. S., Bennett, D., Para, M. F., Beatty, C. C., Jones, C. E., & Balfour, H. H. (1994). Foscarnet for suppression of human immunodeficiency virus replication. Antimicrobial agents and chemotherapy, 38(3), 604-607. https://doi.org/10.1128/AAC.38.3.604