While the influence of orphanin FQ (OFQ) on the regulation of food intake has been substantiated, little is known about feeding-related brain regions that mediate OFQ-induced feeding. To further investigate this, we injected OFQ intracerebroventricularly and evaluated c-Fos immunoreactivity in brain areas thought to be involved in the regulation of food intake. Altered c-Fos expression as a consequence of OFQ injection was observed in the nucleus of the solitary tract, paraventricular nucleus of the hypothalamus, supraoptic nucleus, central nucleus of amygdala, lateral septal nucleus and lateral habenular nucleus. Presumably, OFQ modulates food ingestion through its action on these brain regions, most probably by activating feeding signals as well as suppressing satiety mechanisms. (C) 2000 Published by Elsevier Science B.V.
Bibliographical noteFunding Information:
This work was supported by the Department of Veterans Affairs, by National Institute of Drug Abuse Grant DA-03999 and by the National Institutes of Diabetes and Digestive and Kidney Disease Grant DK-42698 and P30 DK-50456.
Copyright 2007 Elsevier B.V., All rights reserved.
- Intracerebroventricular administration
- Nociceptin/orphanin FQ