Formation of tryptanthrin compounds upon Oxone-induced dimerization of indole-3-carbaldehydes

Amber C. Nelson, Emily S. Kalinowski, Taylor L. Jacobson, Peter Grundt

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26 Scopus citations


Tryptanthrin is a natural product with numerous important pharmacological properties. Tryptanthrin and its analogs are commonly prepared by condensation of isatoic anhydride and isatin. In this Letter we investigate the formation of tryptanthrin derivatives upon Oxone-induced oxidative dimerization of indole-3-carbaldehydes.

Original languageEnglish (US)
Pages (from-to)6804-6806
Number of pages3
JournalTetrahedron Letters
Issue number50
StatePublished - Dec 11 2013

Bibliographical note

Funding Information:
This study was supported by funds from the University of Minnesota Undergraduate Research Program (UROP) and the NSF (Grant CHE-0922366 for X-ray diffractometer).


  • Natural product synthesis
  • Oxidation
  • Tryptanthrin


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