Incubations of estradiol with human and MT/W9a-B rat mammary tumors showed the formation of a non-polar metabolite of estradiol linked with a fatty acid at the 17-position. Studies involving incubations of3H-estradiol and 14C-stearic acid and 14C-oleic acid showed that these tumors formed both the oleoyl and stearyl esters of estradiol and that the percent of oleoyl ester present in the nonpolar metabolite fraction ranged between 19% to 25% while that of stearyl ranged from 10% to 16%. The physiological significance of these results are discussed.
Bibliographical noteFunding Information:
This investigation was supported in part by grant CA 20530 from NIH and the Graduate School, University The technical assistance of Robert lverson is greatly
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