Formation of diastereomeric benzo[a]pyrene diol epoxide-guanine adducts in p53 gene-derived DNA sequences

Chemistry

• Diastereomer 100%
• Benzo[a]pyrene 100%
• DNA Sequence 100%
• formation 100%
• Epoxide 100%
• Guanine 100%
• Diol 100%
• Protein P53 100%
• Tandem Mass Spectrometry 11%
• DNA 11%
• Metabolite 5%
• Electrospray Ionization 5%
• Polycyclic Aromatic Hydrocarbons 5%
• Stereoisomer 5%
• High Performance Liquid Chromatography 5%
• Smoke 5%
• Capillary HPLC 5%
• Stable Isotope 5%
• Dinucleotide 5%
• Enzymatic Hydrolysis 5%
• 5-Methylcytosine 5%
• Tumor Suppressor Protein 5%

Keyphrases

• DNA Sequencing 100%
• Benzo(a)pyrene 100%
• Guanine 100%
• P53 Gene 100%
• Diol Epoxide 100%
• Codon 11%
• 15N Labeling 11%
• Diastereomers 11%
• Lung Cancer 5%
• Tobacco Carcinogens 5%
• Tobacco Smoke 5%
• Double Strand 5%
• Polycyclic Aromatic Hydrocarbons 5%
• Oligodeoxynucleotide 5%
• Genetic Changes 5%
• Lung Tumor 5%
• Polymerase Chain Reaction 5%
• Chemical Structure 5%
• Incision 5%
• Electrospray Ionization Mass Spectrometry 5%
• Ligation 5%
• P53 Tumor Suppressor Gene 5%
• Capillary HPLC 5%
• DNA Duplex 5%
• Enzymatic Hydrolysis 5%
• Stereoisomers 5%
• Guanine nucleotide 5%
• Endonuclease 5%
• Stable Isotope Labeling 5%
• UvrABC 5%
• High Performance Liquid Chromatography-tandem Mass Spectrometry (HPLC-MS/MS) 5%
• 5-hydroxymethylcytosine (5hmC) 5%
• Adduction 5%
• CG Dinucleotide 5%
• Mutational Hotspots 5%
• 2′-Deoxynucleosides 5%
• Transversion mutations 5%
• Mutated p53 5%
• Relative Yield 5%
• Methylated Sites 5%
• Stereochemical Hypothesis 5%
• Bay Area 5%

Pharmacology, Toxicology and Pharmaceutical Science

• Protein P53 100%
• Dihydroxybenzo[a]pyrene Oxide 100%
• Guanine 100%
• High Performance Liquid Chromatography 12%
• Nitrogen 15 12%
• Carcinogen 6%
• Epoxide 6%
• Tumor Suppressor Protein 6%
• Guanine Nucleotide 6%
• Lung Tumor 6%
• Lung Cancer 6%
• Stable Isotope 6%
• Dinucleotide 6%
• Double Stranded DNA 6%
• Oligodeoxynucleotide 6%
• Endonuclease 6%
• 5 Methylcytosine 6%
• Polycyclic Aromatic Hydrocarbon 6%