Formal syntheses of cryptophycin A and arenastatin A

Syed M. Ali, Gunda I. Georg

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Efficient formal syntheses of the tubulin binding antitumor agents cryptophycin A (1) and arenastatin A (2) are detailed. The readily available β-keto ester 4 was subjected to catalytic asymmetric hydrogenation, Frater alkylation, and selective functional group transformations to provide the silyl ether of octanoic acid methyl ester 3, which is the key intermediate for the formal syntheses of the title compounds.

Original languageEnglish (US)
Pages (from-to)1703-1706
Number of pages4
JournalTetrahedron Letters
Issue number10
StatePublished - Mar 10 1997

Bibliographical note

Funding Information:
We gratefully acknowledge the financial support from the National Institutes of Health (CA70369) and a Postdoctoral Fellowship from the Kansas Health Foundation to S. M. Ali.


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