Force spectroscopy of single DNA and RNA molecules

Mark C. Williams, Ioulia Rouzina

Research output: Contribution to journalReview articlepeer-review

149 Scopus citations


Experiments in which single molecules of RNA and DNA are stretched, and the resulting force as a function of extension is measured have yielded new information about the physical, chemical and biological properties of these important molecules. The behavior of both single-stranded and double-stranded nucleic acids under changing solution conditions, such as ionic strength, pH and temperature, has been studied in detail. There has also been progress in using these techniques to study both the kinetics and equilibrium thermodynamics of DNA-protein interactions. These studies generate unique insights into the functions of these proteins in the cell.

Original languageEnglish (US)
Pages (from-to)330-336
Number of pages7
JournalCurrent Opinion in Structural Biology
Issue number3
StatePublished - Jun 1 2002

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