For whom the bell tolls? DING proteins in health and disease

Anne Berna, François Bernier, Eric Chabrière, Mikael Elias, Ken Scott, Andrew Suh

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

DING proteins, identified mainly by their eponymous N-terminal sequences, are ubiquitous in living organisms. Amongst bacteria, they are common in pseudomonads, and have been characterised with respect to genetics and structure. They form part of a wider family of phosphate-binding proteins, with emerging roles in phosphate acquisition and pathogenicity. Many DING proteins have been isolated in eukaryotes, in which they have been associated with very diverse biological activities, often in the context of possible signalling roles. Disease states in which DING proteins have been implicated include rheumatoid arthritis, lithiasis, atherosclerosis, some tumours and tumour-associated cachexia, and bacterial and viral adherence. Complete genetic and structural characterisation of eukaryotic DING genes and proteins is still lacking, though the phosphate-binding site seems to be conserved. Whether as bacterial proteins related to bacterial pathogenicity, or as eukaryotic components of biochemical signalling systems, DING proteins require further study.

Original languageEnglish (US)
Pages (from-to)2205-2218
Number of pages14
JournalCellular and Molecular Life Sciences
Volume66
Issue number14
DOIs
StatePublished - Jul 1 2009

Keywords

  • Bacteria
  • DING protein
  • Eukaryotes
  • Pathogenesis
  • Phosphate deprivation
  • Phosphate-binding protein
  • Transcriptional modulation

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