Following the expression of a kidney-specific gene from early development to adulthood.

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Ksp-cadherin (Cadherin 16) is a unique, tissue-specific member of the cadherin family of cell adhesion proteins that is expressed exclusively in tubular epithelial cells in the adult kidney and developing genitourinary (GU) tract. Since its original identification in 1995, Ksp-cadherin has proven to be a useful experimental model for studies of kidney-specific and developmental gene regulation. These investigations have led to the creation of new strains of transgenic mice that will be useful for studies of renal cell lineage and tissue-specific gene targeting. Recent studies have also identified Ksp-cadherin as the first kidney-specific promoter that it is regulated by HNF-1beta (hepatocyte nuclear factor-1beta), a transcription factor that has been implicated in human renal cystic disease.

Original languageEnglish (US)
JournalNephron. Experimental nephrology
Volume94
Issue number1
StatePublished - Jan 1 2003

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Cadherins
Kidney
Genes
Hepatocyte Nuclear Factor 1-beta
Cystic Kidney Diseases
Developmental Genes
Gene Targeting
Cell Lineage
Cell Adhesion
Transgenic Mice
Transcription Factors
Theoretical Models
Epithelial Cells
Proteins

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Following the expression of a kidney-specific gene from early development to adulthood. / Igarashi, Peter.

In: Nephron. Experimental nephrology, Vol. 94, No. 1, 01.01.2003.

Research output: Contribution to journalReview article

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