Follow-up of Children with Kernicterus in Kano, Nigeria

Zubaida Ladan Farouk, Abdussalam Muhammed, Safiya Gambo, Maria Mukhtar-Yola, Shehu Umar Abdullahi, Tina M. Slusher

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: Acute bilirubin encephalopathy (ABE) is associated with long-term sequelae (kernicterus). It continues to be a significant issue in our region of Nigeria, accounting for much morbidity and mortality. Herein we report the outcome of neonates with ABE seen at our centre. Methodology: We established a surveillance of children who had ABE and returned to follow-up from prospective cases of ABE (2012-2014). ABE was diagnosed based on a bilirubin-induced neurologic dysfunction score of ≥ 1. Kernicterus was subsequently established based on a history of developmental delays, hearing impairments and abnormal physical and neurologic examinations at follow-up age ≥3 months. Result: Five hundred fifty-one neonates had hyperbilirubinaemia of whom 104 (18.8%) had ABE. Mean transcutaneous bilirubin using the Ingram icterometer was 18.3 mg/dl  ±  SD 1.9 [(12.5-19.1), total serum bilirubin of 18.1 ± 10.9] (range: 10.3-64 mg/dl). Sixty-five infants returned for follow-up (41 males and 24 females); mean age 9 months (22 days to 17 months). Most (58 of 65; 89.2%) had abnormal neurological findings and 15 (25.9%) had probable kernicterus. Conclusion: There is a critical need for a National Kernicterus Registry to document all cases of kernicterus and formulate an effective treatment and prevention policy.

Original languageEnglish (US)
Pages (from-to)176-182
Number of pages7
JournalJournal of tropical pediatrics
Volume64
Issue number3
DOIs
StatePublished - Jun 1 2018

Fingerprint

Kernicterus
Nigeria
Bilirubin
Newborn Infant
Hyperbilirubinemia
Neurologic Examination
Neurologic Manifestations
Hearing Loss
Physical Examination
Registries

PubMed: MeSH publication types

  • Journal Article

Cite this

Farouk, Z. L., Muhammed, A., Gambo, S., Mukhtar-Yola, M., Umar Abdullahi, S., & Slusher, T. M. (2018). Follow-up of Children with Kernicterus in Kano, Nigeria. Journal of tropical pediatrics, 64(3), 176-182. https://doi.org/10.1093/tropej/fmx041

Follow-up of Children with Kernicterus in Kano, Nigeria. / Farouk, Zubaida Ladan; Muhammed, Abdussalam; Gambo, Safiya; Mukhtar-Yola, Maria; Umar Abdullahi, Shehu; Slusher, Tina M.

In: Journal of tropical pediatrics, Vol. 64, No. 3, 01.06.2018, p. 176-182.

Research output: Contribution to journalArticle

Farouk, ZL, Muhammed, A, Gambo, S, Mukhtar-Yola, M, Umar Abdullahi, S & Slusher, TM 2018, 'Follow-up of Children with Kernicterus in Kano, Nigeria', Journal of tropical pediatrics, vol. 64, no. 3, pp. 176-182. https://doi.org/10.1093/tropej/fmx041
Farouk ZL, Muhammed A, Gambo S, Mukhtar-Yola M, Umar Abdullahi S, Slusher TM. Follow-up of Children with Kernicterus in Kano, Nigeria. Journal of tropical pediatrics. 2018 Jun 1;64(3):176-182. https://doi.org/10.1093/tropej/fmx041
Farouk, Zubaida Ladan ; Muhammed, Abdussalam ; Gambo, Safiya ; Mukhtar-Yola, Maria ; Umar Abdullahi, Shehu ; Slusher, Tina M. / Follow-up of Children with Kernicterus in Kano, Nigeria. In: Journal of tropical pediatrics. 2018 ; Vol. 64, No. 3. pp. 176-182.
@article{3a6c6cb3272d4f9ab97441842659ba16,
title = "Follow-up of Children with Kernicterus in Kano, Nigeria",
abstract = "Introduction: Acute bilirubin encephalopathy (ABE) is associated with long-term sequelae (kernicterus). It continues to be a significant issue in our region of Nigeria, accounting for much morbidity and mortality. Herein we report the outcome of neonates with ABE seen at our centre. Methodology: We established a surveillance of children who had ABE and returned to follow-up from prospective cases of ABE (2012-2014). ABE was diagnosed based on a bilirubin-induced neurologic dysfunction score of ≥ 1. Kernicterus was subsequently established based on a history of developmental delays, hearing impairments and abnormal physical and neurologic examinations at follow-up age ≥3 months. Result: Five hundred fifty-one neonates had hyperbilirubinaemia of whom 104 (18.8{\%}) had ABE. Mean transcutaneous bilirubin using the Ingram icterometer was 18.3 mg/dl  ±  SD 1.9 [(12.5-19.1), total serum bilirubin of 18.1 ± 10.9] (range: 10.3-64 mg/dl). Sixty-five infants returned for follow-up (41 males and 24 females); mean age 9 months (22 days to 17 months). Most (58 of 65; 89.2{\%}) had abnormal neurological findings and 15 (25.9{\%}) had probable kernicterus. Conclusion: There is a critical need for a National Kernicterus Registry to document all cases of kernicterus and formulate an effective treatment and prevention policy.",
author = "Farouk, {Zubaida Ladan} and Abdussalam Muhammed and Safiya Gambo and Maria Mukhtar-Yola and {Umar Abdullahi}, Shehu and Slusher, {Tina M.}",
year = "2018",
month = "6",
day = "1",
doi = "10.1093/tropej/fmx041",
language = "English (US)",
volume = "64",
pages = "176--182",
journal = "Journal of Tropical Pediatrics",
issn = "0142-6338",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Follow-up of Children with Kernicterus in Kano, Nigeria

AU - Farouk, Zubaida Ladan

AU - Muhammed, Abdussalam

AU - Gambo, Safiya

AU - Mukhtar-Yola, Maria

AU - Umar Abdullahi, Shehu

AU - Slusher, Tina M.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Introduction: Acute bilirubin encephalopathy (ABE) is associated with long-term sequelae (kernicterus). It continues to be a significant issue in our region of Nigeria, accounting for much morbidity and mortality. Herein we report the outcome of neonates with ABE seen at our centre. Methodology: We established a surveillance of children who had ABE and returned to follow-up from prospective cases of ABE (2012-2014). ABE was diagnosed based on a bilirubin-induced neurologic dysfunction score of ≥ 1. Kernicterus was subsequently established based on a history of developmental delays, hearing impairments and abnormal physical and neurologic examinations at follow-up age ≥3 months. Result: Five hundred fifty-one neonates had hyperbilirubinaemia of whom 104 (18.8%) had ABE. Mean transcutaneous bilirubin using the Ingram icterometer was 18.3 mg/dl  ±  SD 1.9 [(12.5-19.1), total serum bilirubin of 18.1 ± 10.9] (range: 10.3-64 mg/dl). Sixty-five infants returned for follow-up (41 males and 24 females); mean age 9 months (22 days to 17 months). Most (58 of 65; 89.2%) had abnormal neurological findings and 15 (25.9%) had probable kernicterus. Conclusion: There is a critical need for a National Kernicterus Registry to document all cases of kernicterus and formulate an effective treatment and prevention policy.

AB - Introduction: Acute bilirubin encephalopathy (ABE) is associated with long-term sequelae (kernicterus). It continues to be a significant issue in our region of Nigeria, accounting for much morbidity and mortality. Herein we report the outcome of neonates with ABE seen at our centre. Methodology: We established a surveillance of children who had ABE and returned to follow-up from prospective cases of ABE (2012-2014). ABE was diagnosed based on a bilirubin-induced neurologic dysfunction score of ≥ 1. Kernicterus was subsequently established based on a history of developmental delays, hearing impairments and abnormal physical and neurologic examinations at follow-up age ≥3 months. Result: Five hundred fifty-one neonates had hyperbilirubinaemia of whom 104 (18.8%) had ABE. Mean transcutaneous bilirubin using the Ingram icterometer was 18.3 mg/dl  ±  SD 1.9 [(12.5-19.1), total serum bilirubin of 18.1 ± 10.9] (range: 10.3-64 mg/dl). Sixty-five infants returned for follow-up (41 males and 24 females); mean age 9 months (22 days to 17 months). Most (58 of 65; 89.2%) had abnormal neurological findings and 15 (25.9%) had probable kernicterus. Conclusion: There is a critical need for a National Kernicterus Registry to document all cases of kernicterus and formulate an effective treatment and prevention policy.

UR - http://www.scopus.com/inward/record.url?scp=85071284852&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071284852&partnerID=8YFLogxK

U2 - 10.1093/tropej/fmx041

DO - 10.1093/tropej/fmx041

M3 - Article

C2 - 28605485

AN - SCOPUS:85071284852

VL - 64

SP - 176

EP - 182

JO - Journal of Tropical Pediatrics

JF - Journal of Tropical Pediatrics

SN - 0142-6338

IS - 3

ER -