TY - JOUR
T1 - Follistatin-like protein-1 is a novel proinflammatory molecule
AU - Miyamae, Takako
AU - Marinov, Anthony D.
AU - Sowders, Dawn
AU - Wilson, David C.
AU - Devlin, Jason
AU - Boudreau, Robert
AU - Robbins, Paul
AU - Hirsch, Raphael
PY - 2006/10/1
Y1 - 2006/10/1
N2 - While analyzing gene expression in collagen-induced arthritis, we discovered that a poorly characterized gene, follistatin-like protein 1 (FSTL-1), is highly overexpressed in mouse paws during early arthritis, especially at the interface of synovial pannus and eroding bone. In this study, we show that FSTL-1 is a novel proinflammatory molecule with a previously unrecognized role in inflammation. Transfection of FSTL-1 into macrophages and fibroblasts leads to up-regulation of proinflammatory cytokines, including IL-1β, TNF-α, and IL-6. Overexpression of FSTL-1 in mouse paws by gene transfer results in severe paw swelling and arthritis.
AB - While analyzing gene expression in collagen-induced arthritis, we discovered that a poorly characterized gene, follistatin-like protein 1 (FSTL-1), is highly overexpressed in mouse paws during early arthritis, especially at the interface of synovial pannus and eroding bone. In this study, we show that FSTL-1 is a novel proinflammatory molecule with a previously unrecognized role in inflammation. Transfection of FSTL-1 into macrophages and fibroblasts leads to up-regulation of proinflammatory cytokines, including IL-1β, TNF-α, and IL-6. Overexpression of FSTL-1 in mouse paws by gene transfer results in severe paw swelling and arthritis.
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U2 - 10.4049/jimmunol.177.7.4758
DO - 10.4049/jimmunol.177.7.4758
M3 - Article
C2 - 16982916
AN - SCOPUS:33749131747
SN - 0022-1767
VL - 177
SP - 4758
EP - 4762
JO - Journal of Immunology
JF - Journal of Immunology
IS - 7
ER -