Follistatin-like protein-1 is a novel proinflammatory molecule

Takako Miyamae, Anthony D. Marinov, Dawn Sowders, David C. Wilson, Jason Devlin, Robert Boudreau, Paul Robbins, Raphael Hirsch

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

While analyzing gene expression in collagen-induced arthritis, we discovered that a poorly characterized gene, follistatin-like protein 1 (FSTL-1), is highly overexpressed in mouse paws during early arthritis, especially at the interface of synovial pannus and eroding bone. In this study, we show that FSTL-1 is a novel proinflammatory molecule with a previously unrecognized role in inflammation. Transfection of FSTL-1 into macrophages and fibroblasts leads to up-regulation of proinflammatory cytokines, including IL-1β, TNF-α, and IL-6. Overexpression of FSTL-1 in mouse paws by gene transfer results in severe paw swelling and arthritis.

Original languageEnglish (US)
Pages (from-to)4758-4762
Number of pages5
JournalJournal of Immunology
Volume177
Issue number7
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

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