Focusing capillary optics for use in solution small-angle X-ray scattering

Jessica S. Lamb, Sterling Cornaby, Kurt Andresen, Lisa Kwok, Hye Yoon Park, Xiangyun Qiu, Detlef M. Smilgies, Donald H. Bilderback, Lois Pollack

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Measurements of the global conformation of macromolecules can be carried out using small-angle X-ray scattering (SAXS). Glass focusing capillaries, manufactured at the Cornell High Energy Synchrotron Source (CHESS), have been successfully employed for SAXS measurements on the heme protein cytochrome c. These capillaries provide high X-ray flux into a spot size of tens of micrometres, permitting short exposures of small-volume samples. Such a capability is ideal for use in conjunction with microfluidic mixers, where time resolution may be determined by beam size and sample volumes are kept small to facilitate mixing and conserve material.

Original languageEnglish (US)
Article numberce5006
Pages (from-to)193-195
Number of pages3
JournalJournal of Applied Crystallography
Issue number1
StatePublished - Jan 12 2007
Externally publishedYes


  • Focusing capillary optics
  • Macromolecular crystallography


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