We present a concept for integrating focused ultrasound (FUS) with electrophysiological neuroimaging, in order to achieve high spatiotemporal resolution brain imaging. This approach, which we are tentatively calling acousto-electrophysiological neuroimaging, leverages on the spatial focality and noninvasiveness of FUS and may potentially lead to a noninvasive human brain imaging modality with high resolution in both space and time domains. By the use of modulated FUS, spatial selectivity can be accomplished for high-resolution electrophysiological neuroimaging. Frequency shifting in resulting magnetic signals (using modulated FUS) may potentially open the door for a room temperature magnetoencephalography device.
Bibliographical noteFunding Information:
This work was supported in part by the National Science Foundation under Grant CBET-1450956, by the National Institutes of Health under Grant NS096761, Grant EB021027, Grant AT009263, Grant EY023101, and Grant HL117664.
- Electroencephalography (EEG)
- electrophysiological neuroimaging
- magnetoencephalography (MEG)
- source imaging
- source localization