fMRI and transcranial electrical stimulation (tES): A systematic review of parameter space and outcomes

Peyman Ghobadi-Azbari, Asif Jamil, Fatemeh Yavari, Zeinab Esmaeilpour, Nastaran Malmir, Rasoul Mahdavifar-Khayati, Ghazaleh Soleimani, Yoon Hee Cha, A. Duke Shereen, Michael A. Nitsche, Marom Bikson, Hamed Ekhtiari

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The combination of non-invasive brain stimulation interventions with human brain mapping methods have supported research beyond correlational associations between brain activity and behavior. Functional MRI (fMRI) partnered with transcranial electrical stimulation (tES) methods, i.e., transcranial direct current (tDCS), transcranial alternating current (tACS), and transcranial random noise (tRNS) stimulation, explore the neuromodulatory effects of tES in the targeted brain regions and their interconnected networks and provide opportunities for individualized interventions. Advances in the field of tES-fMRI can be hampered by the methodological variability between studies that confounds comparability/replicability. In order to explore variability in the tES-fMRI methodological parameter space (MPS), we conducted a systematic review of 222 tES-fMRI experiments (181 tDCS, 39 tACS and 2 tRNS) published before February 1, 2019, and suggested a framework to systematically report main elements of MPS across studies. Publications dedicated to tRNS-fMRI were not considered in this systematic review. We have organized main findings in terms of fMRI modulation by tES. tES modulates activation and connectivity beyond the stimulated areas particularly with prefrontal stimulation. There were no two studies with the same MPS to replicate findings. We discuss how to harmonize the MPS to promote replication in future studies.

Original languageEnglish (US)
Article number110149
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume107
DOIs
StatePublished - Apr 20 2021

Bibliographical note

Publisher Copyright:
© 2020

Keywords

  • Functional magnetic resonance imaging (fMRI)
  • Methodological parameter space (MPS)
  • Transcranial alternating current stimulation (tACS)
  • Transcranial direct current stimulation (tDCS)
  • Transcranial electrical stimulation (tES)

PubMed: MeSH publication types

  • Journal Article
  • Review

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