Abstract
Sixty-eight male and female individuals with both DSM-IV diagnoses of cocaine dependence and major depressive disorder were randomly assigned to one of two medication conditions (placebo vs. 40 mg per day) as part of a double-blind, placebo-controlled clinical efficacy trial of fluoxetine for the treatment of this dual diagnosis. During the 12-week outpatient treatment phase all participants also received individual cognitive-behavioral psychotherapy targeting both cocaine use and depression. Depressive symptoms remitted as a function of time in treatment, with no significant medication effects found. Fewer cocaine positive urines were found during the first 6 weeks of treatment in the placebo group compared with the 40-mg group. Cocaine use and depressive symptoms during treatment were significantly correlated. The findings fail to support the role of fluoxetine for treatment of cocaine use and depression in dually-diagnosed patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 207-214 |
| Number of pages | 8 |
| Journal | Drug and alcohol dependence |
| Volume | 63 |
| Issue number | 3 |
| DOIs | |
| State | Published - Aug 1 2001 |
Bibliographical note
Funding Information:Support for this research was provided by Grant DA-08654 and from our Substance Abuse Medication Development Research Center Grant (DA P50-9262), both from the National Institute on Drug Abuse, with additional support from the Department of Psychiatry and Behavioral Sciences, University of Texas-Houston. The authors would like to acknowledge the dedicated efforts of the staff at the Treatment Research Clinic for their support of this study.
Keywords
- Cocaine
- Depression
- Dual-diagnosis
- Fluoxetine
- Treatment
