Fluoxetine treatment of cocaine-dependent patients with major depressive disorder

Joy M. Schmitz, Patricia Averill, Angela L. Stotts, F. Gerard Moeller, Howard M. Rhoades, John Grabowski

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Sixty-eight male and female individuals with both DSM-IV diagnoses of cocaine dependence and major depressive disorder were randomly assigned to one of two medication conditions (placebo vs. 40 mg per day) as part of a double-blind, placebo-controlled clinical efficacy trial of fluoxetine for the treatment of this dual diagnosis. During the 12-week outpatient treatment phase all participants also received individual cognitive-behavioral psychotherapy targeting both cocaine use and depression. Depressive symptoms remitted as a function of time in treatment, with no significant medication effects found. Fewer cocaine positive urines were found during the first 6 weeks of treatment in the placebo group compared with the 40-mg group. Cocaine use and depressive symptoms during treatment were significantly correlated. The findings fail to support the role of fluoxetine for treatment of cocaine use and depression in dually-diagnosed patients.

Original languageEnglish (US)
Pages (from-to)207-214
Number of pages8
JournalDrug and alcohol dependence
Volume63
Issue number3
DOIs
StatePublished - Aug 1 2001

Fingerprint

Fluoxetine
Major Depressive Disorder
Cocaine
Depression
Placebos
Therapeutics
Dual (Psychiatry) Diagnosis
Cocaine-Related Disorders
Controlled Clinical Trials
Cognitive Therapy
Diagnostic and Statistical Manual of Mental Disorders
Outpatients
Urine

Keywords

  • Cocaine
  • Depression
  • Dual-diagnosis
  • Fluoxetine
  • Treatment

Cite this

Fluoxetine treatment of cocaine-dependent patients with major depressive disorder. / Schmitz, Joy M.; Averill, Patricia; Stotts, Angela L.; Moeller, F. Gerard; Rhoades, Howard M.; Grabowski, John.

In: Drug and alcohol dependence, Vol. 63, No. 3, 01.08.2001, p. 207-214.

Research output: Contribution to journalArticle

Schmitz, Joy M. ; Averill, Patricia ; Stotts, Angela L. ; Moeller, F. Gerard ; Rhoades, Howard M. ; Grabowski, John. / Fluoxetine treatment of cocaine-dependent patients with major depressive disorder. In: Drug and alcohol dependence. 2001 ; Vol. 63, No. 3. pp. 207-214.
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