Fluoroquinolones influence the intracellular calcium handling in individuals susceptible to malignant hyperthermia

Thomas Metterlein, Frank Schuster, Lukas Tadda, Martin Hager, Sheila Muldoon, John Capacchione, Norbert Roewer, Martin Anetseder

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Introduction: The mechanisms of fluoroquinol one-induced myotoxicity are unknown but an involvement of intracellular calcium handling is suspected. An in vitro contracture test used to investigate cellular processes in malignant hyperthermia(MH) can be applied to study the effects of fluoroquinolones. Methods: With approval of the locet al.hics committee, muscle biopsies of 18 MH susceptible (MHS) and 12 MHS non susceptible(MHN) pigs were performed. Individual bundles were mounted on an isometric force transducer, preloaded, and electrically stimulated. After equilibration they were exposed to ciprofloxacin or levofloxacin. The measured baseline tension was analyzed (Wilcoxon test: P < 0.05). Results: There were no differences in weight, length, or predrug tension between the groups. Both levofloxacin an ciprofloxacin induced significant contractures in MHS muscle bundles but not in MHN. Conclusions: Fluoroquinolones appear to have a pathological influence on intracellular calcium handling. A pre-existing impairment of the calcium homeostasis, however, seems to be necessary for this behavior.

Original languageEnglish (US)
Pages (from-to)208-212
Number of pages5
JournalMuscle and Nerve
Volume44
Issue number2
DOIs
StatePublished - Aug 1 2011

Keywords

  • Calcium handling
  • Fluoroquinolones
  • In vitro contracture testing
  • Malignant hyperthermia
  • Myotoxicity
  • Rhabdomyolysis

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