Fluoroquinolone resistance in anaerobic bacteria following exposure to levofloxacin, trovafloxacin, and sparfloxacin in an in vitro pharmacodynamic model

G. H. Ross, D. H. Wright, L. B. Hovde, M. L. Peterson, J. C. Rotschafer

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

This investigation explored pharmacodynamic characteristics of fluoroquinolones against Bacteroides thetaiotamicron and the potential for development of resistance. An in vitro model was used to generate kill curves with three fluoroquinolones at various area under the concentration-time curve (AUC)/MIC ratios. Concentration-independent killing was observed. Increases in MICs were noted following exposure to fluoroquinolones at AUC/MIC ratios of 6 to 14.

Original languageEnglish (US)
Pages (from-to)2136-2140
Number of pages5
JournalAntimicrobial agents and chemotherapy
Volume45
Issue number7
DOIs
StatePublished - Jul 10 2001

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