Fluorescent assay for estimating the biding of erythromycin derivatives to ribosomes

P. Brandt Rauf, R. Vince, R. LeMahieu, S. Pestlea

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A fluorescent erythromycin derivative was used to determine the binding of erythromycin derivatives to ribosomes. The assay is rapid, sensitive, and convenient. Because measurements are made in solution, they represent equilibrium conditions, unlike filter binding assays which perturb the equilibrium. Results correlate well with measurements made by other techniques.

Original languageEnglish (US)
Pages (from-to)88-94
Number of pages7
JournalAntimicrobial agents and chemotherapy
Volume14
Issue number1
DOIs
StatePublished - 1978

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