Fluorescence sensing of a ribonucleoside 5'-triphosphate

Steven Patterson, Bradley D. Smith, Richard E. Taylor

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Conjugation of a fluorescent saccharide sensor to poly(allylamine) produces a sensing compound with selectivity for ribonucleoside 5'-triphosphate. An association constant (log K(a)) of 5.6 was determined for uridine 5'-triphosphate in pH 7.3 phosphate solution (15 mM, 298 K), whereas log K(a) was less than 2 for uridine, uridine 5'-monophosphate, and uridine 5'-diphosphate.

Original languageEnglish (US)
Pages (from-to)6323-6326
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number36
DOIs
StatePublished - Sep 8 1997
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by a Bayer Postdoctoral Fellowship and the National Science Foundation (USA).

Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.

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